GENES BIOMARKERS IN AUTISM: BRAIN DEVELOPMENT AND FUNCTION

Dahrizal Dahmayanti Saridewi, Abdul Karim Norwahidah

Abstract


Autism is childhood neuropsychiatric disorder despite exhibiting high heritability and has largely eluded efforts to identify specific genetic variants of biomarkers. This neuropsychiatric disorder is characterized by social and communicative deficits and ritualistic-repetitive behaviour that are detectable in early childhood. It has been reported that some candidate genes has been found in autism children brains. The candidate genes include aspects of neurogenesis, neuronal migration, maturation, differentiation, and degeneration. Some of researchers had reported the effects of the mutated and sufficiency of the candidate genes in autism brain which believed that might involved in the mechanism and causes deficit in social behaviour language impairment and repetitive behaviour. In this review, we will summarize the gene candidate which found in autism children brains and their effect of their cognitive function.

Keywords: Autism; Gene biomarkers; Brain development.


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DOI: https://doi.org/10.5455/ijcbr.2018.42.16

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