Reproductive Health of Women: a comprehensive review

Authors

  • Imran Gani Department of Pharmaceutical Sciences, University of Kashmir
  • Irfat Ara Research officer, Regional Research Institute of Unani Medicine, Srinagar, Jammu and Kashmir, India
  • Mohd Altaf Dar Department of Pharmacology, CT Institute of Pharmaceutical Sciences, PTU, Jalandhar Punjab

Keywords:

Women health, adulthood, fertility, sexual health, menstruation

Abstract

Full access to sexual and reproductive health is a fundamental human right. Women and girls around the world, especially those living in poverty, have little or no access to reproductive health and rights information and services. Discrimination, shame, restrictive laws and regulations, and long-standing traditions are just some of the existing barriers to sexual and reproductive health. There is evidence that these rights affect not only individual women, but also families, communities and economies, but progress has been slow. Women's lifestyles have evolved throughout history. Life used to be difficult for most women. Many women have had unwanted pregnancies. Childbirth used to be dangerous and often ended in the death of the mother. Most women have never suffered menopause or senility in the past because they did not live long enough. Reproductive health is an important aspect of an individual's overall development and well-being. It may be the result of positive parenting, which is essential in adolescence and lays the foundation for good health in adulthood and beyond reproductive age, in both men and women. Female reproductive life does not begin at puberty and end at menopause. Also, a man's reproductive lifespan doesn't end when he becomes less likely to have more children. It is present and essential at every stage of human development and maturity. Reproductive health needs vary by age and stage of life. However, there are long-term effects throughout life, with each stage having a significant impact on future well-being.

Keywords: Women health, adulthood, fertility, sexual health, menstruation.

Downloads

Download data is not yet available.

Reproductive Health of Women: a comprehensive review

Introduction

Reproductive health is an important part of human growth and overall health. This can be essential health education for young people, and can lay the foundation for good health for men and women in adulthood and beyond the reproductive years. Reproduction does not begin at puberty and ends when a woman enters menopause or a man is unable to bear children. Rather, it follows the entire life cycle of an individual and is critically important at various stages of development and maturation. Individual reproductive health needs can vary at each stage of life. The effects are also cumulative throughout life, and each stage has important consequences for future well-being. If reproductive health problems are not addressed at any stage, it can set the stage for health problems later. This is called the life cycle view of reproductive health. Safe reproductive systems, processes and practices are critical factors for adequate overall health. However, many conditions, both internal and external, can compromise a person’s ability to maintain reproductive health. Remember that events and exposures from prenatal development to late life can determine reproductive health status. Many factors directly affect a person’s reproductive health [1-6]. In addition, the environment in which an individual life, both natural and physical, can present significant risks that directly affect reproductive health. For example, exposure to certain occupations (such as work with harmful chemicals) negatively affects reproductive life. The World Health Organization (WHO) defines reproductive health as a state of complete physical, mental and social well-being, not just the absence of a reproductive disease or diseases. Reproductive health includes all reproductive processes, functions and systems at all stages of a person’s life. This concept says that people have a satisfying and safe sex life and can have intercourse and be flexible when and how often they choose. Men and women have the right to information and the right to choose safe, effective, affordable and acceptable family planning options that are against the law [7-10]. Men and women should be well cared for so that women can get through pregnancy and childbirth safely and give couples the best chance of having a healthy baby. Reproductive health is a global problem, but it is critical for women, especially during their reproductive years. However, in certain areas of reproductive health, men have special expectations about reproductive health and have special responsibilities regarding women’s reproductive health because they have decision-making power. Reproductive health is an integral part of a person’s overall health and a key predictor of quality of life. The WHO definition of reproductive health particularly emphasizes the human right to maintain sexual health. Sexual health is a synthesis of the emotional, intellectual and social aspects of sexuality to make a constructive contribution to the development of personality, communication, relationships and love [11-22]. The three basic principles of sexual health are: 1) the ability to enjoy and control sexual and reproductive behaviour; 2) the ability to avoid an organic disorder or disease affecting sexual and reproductive functions; and 3) the ability to avoid shame, guilt, fear and other psychological factors that can harm sexual relationships. People with reproductive health problems also have a responsible, safe and fulfilling sex life, the freedom to reproduce according to their needs and desires, and the right of men and women to know their options and access to safe, effective, affordable and acceptable methods, fertility management and the right to adequate health services. Reproductive health should be addressed within a framework of good relations and an understanding of the balance between compliance and risk. Reproductive health significantly increases the physical and mental comfort and closeness of people. Disease, abuse, exploitation, unwanted pregnancy and maternal death are all linked to poor reproductive health [23-29].

Reproductive Health: Issues, Development and Definition

As the world integrates economically, politically, geographically and culturally technologically, the population health debate is moving from a local to a global context. The International Conference on Population and Development (ICPD) in 1994 ushered in an era of heightened awareness of population growth issues and was ”an important milestone in expanding the population debate and national and international population policy beyond a demographic focus to include broader issues of reproductive health and human rights”. 179 countries participated in the ICPD. Since then, significant progress has been made towards achieving the ICDP goal of universal access to reproductive health services. As a result, the international community has moved from state-led” population control” to a concept of individual decision-making with majority access to reproductive health care [30-39]. However, deficiencies in reproductive and sexual health are responsible for more than a fifth of the world’s diseases and premature death, and a third of women of childbearing age suffer from disease and death. Over time, the transition to a global environment has also affected the importance of reproductive health and related issues. It can simply relate to the physical and mental well-being of the mother from pregnancy to breastfeeding. The 1994 definition of the International Conference on Population and Development of reproductive health includes important characteristics that distinguish reproductive and sexual health from other aspects of health. Reproductive health is about sociocultural variables, gender roles, and the respect and protection of human rights, including but not limited to sexuality and personal interactions before and after the reproductive years. The International Conference on Population and Development (ICPD) defines reproductive health as ”a state of complete physical, mental and social well-being in all aspects of the reproductive system and its functions and processes, and not simply the absence of disease or illness. People with reproductive health can have a satisfying and safe sex life, as well as the ability to reproduce and the freedom to choose whether, when and how often to do so [40-50]. The International Commission on Population and Development defines reproductive health as ’a combination of tactics, methods and services that promote reproductive health and well-being through the prevention and resolution of reproductive health problems.’ Not only counseling and therapy for reproductive and sexually transmitted diseases, but also sexual health that focuses on improving lives and relationships.” It also addressed the rights of men and women to learn about and access safe, effective, affordable and acceptable family planning and other aspects of their chosen contraceptive methods that do not violate the law and women’s right to adequate health services that enable safe pregnancy and childbirth legislation, international human rights declarations and other consensus documents." The rights are based on the fact that recognizing the basic right of all couples and individuals to freely choose the number, spacing and time of birth of their children responsibly and have the necessary information and resources to achieve the best quality of sexual or reproductive health. This includes their right to choose to reproduce without discrimination, coercion or violence, as recognized in human rights instruments [8, 31, 51-53].

Concept of Reproductive Health

Women need health care to be able to practise their sexual activities safely and effectively. Women’s reproductive health services were added to health technology services in the second half of the 20th century. However, the service was not flawless. In addition to inadequate resource allocation, the main flaw of these services was their ideology. Women were considered the source of reproduction and the object of fertility control. Women were not offered services to achieve the goal. This process benefited women, but they were not at the centre of it. Traditionally, women’s needs have been addressed through the concept of maternal and child health (MCH) [54-67]. The woman’s desires were intertwined with the mother’s needs. MCH programs and services have played a critical role in the preventive and curative health of mothers and children. The success of a healthy child is often at the heart of MCH’s services. Although mothers are very concerned about the success of investments in the reproductive process, little emphasis has been placed on the health risks that mothers face during pregnancy and childbirth, and essential birthing practices and equipment have been created to combat these risks. As a result, the tragedy of maternal mortality has grown to such an extent that it can no longer be ignored. Although family planning programs offer many benefits to women’s quality of life, they have left women with real and unmet concerns [68-77]. Contraception is designed for women to empower themselves by increasing choices and taking control of their fertility, sexuality, health and therefore their lives. Governments and others, on the other hand, may use family planning to control women rather than empower them. Demography was the main driving force behind the family planning movement. Politicians often treated women as objects rather than subjects. Some governments were jaded and did not understand that when women are given a real choice and given the information and tools to make that choice, they will make the best decision for themselves, their communities, and ultimately the planet. The important health needs of the reproductive process have been unmet because women are treated as a means rather than an end. Infertility may not pose a serious physical threat, but it can be a major source of emotional and social distress. It is not fair that society focuses on women’s reproduction while ignoring the pain of those who cannot conceive. Women are exposed to the possibility of unwanted pregnancy during intercourse. It also exposes many women to another serious threat, sexually transmitted diseases, including HIV. Family planning programs that focus only on demographics fail to understand the importance of this critical need for women. MCH focuses on women when and how they reproduce to ensure a healthy child for society, but often ignores other health needs of women that are not related to reproduction. Women’s reproductive health requirements are not limited to their reproductive years. The girl, the young girl, the mature adult, and the old woman have health care needs in future or past reproductive roles. The social attitude where women are seen as a means rather than an end is much more widespread. Women’s services are often veterinary services. Proponents of girls’ education emphasize the benefits of education for child survival and health, and its effect on reducing birth rates. Because of the needs of the fetus and breastfeeding the newborn, nutrition is essential for women. Even in the face of the tragedy of maternal mortality, investing in keeping women alive is justified because their existence is critical to the survival of children. In response to the fragmentation and orientation of current services, the concept of reproductive health has recently emerged [78-82]. The broader idea of “reproductive health” gives a holistic and integrated approach to the requirements of reproductive health. As subjects and not as objects, women are focused as goals and not as methods [83, 84].

Reproductive Health Problems of Women

Women’s health needs can be broadly divided into four groups. First, women have clear sexual and reproductive health requirements. Second, women have developed reproductive systems that are exposed to disorders or diseases even before or after they are introduced. Third, women are prone to the same diseases that affect men in other body systems. Diseases often differ from those of men due to genetic makeup, hormonal environment or sexual behaviour. Diseases of other body systems or their treatment may interact with reproductive system or functional problems. Fourth, women suffer from social ills that harm their physical, mental or social well-being. Examples of this include female genital mutilation, sexual abuse and domestic violence. The reproductive system plays a vital role in the functioning, dysfunction and disease of women. It is different for men. A significant weight of women’s disease is how society treats or mistreats their reproductive functions and reproductive systems because of their gender. While males die more due to their so-called ”vices,” females often suffer due to their natural physiological functions to ensure the survival of the species and the tasks that come with it [85-88].

Women’s health is not only a prerequisite for physical well-being, but also an expression of many roles as wife, mother and health worker at home and in a changed environment, even as a salaried worker. In the past, women suffered from neglect and discrimination that kept their health below the prescribed level. Women are still tamed and controlled by a complex sociocultural network that requires them to be tactful and not talk about their many health problems. They were conditioned by strict social systems to meet their needs and generalize themselves into a philosophy of self-renunciation, self-destruction and service. That is why women are threatened twice, on the one hand by an unequal socio-economic system and on the other by subjugation and deprivation in their homes and society [89, 90].

Reproductive and Sexual Health Services

Women’s health is not only a prerequisite for physical well-being, but also an expression of many roles as wife, mother and health worker at home and in a changed environment, even as a salaried worker. In the past, women suffered from neglect and discrimination that kept their health below the prescribed level. Women are still tamed and controlled by a complex sociocultural network that requires them to be tactful and not talk about their many health problems. They were conditioned by strict social systems to meet their needs and generalize themselves into a philosophy of self-renunciation, self-destruction and service. That is why women are threatened twice, on the one hand by an unequal socio-economic system and on the other by subjugation and deprivation in their homes and society [91-94].

These treatments can only be provided in their entirety through these services. This study only looked at some key elements such as reproductive health and related areas such as antenatal care (ANC), which refers to pregnancy care provided by a doctor or health professional in a medical facility or at home. Prenatal care should ideally monitor the pregnancy for signs and symptoms of complications, diagnose and treat pre-existing and coexisting pregnancy conditions, and provide advice and guidance on childbirth, prevention, nutrition, postpartum care, and related issues. Treatment is another important aspect of reproductive health. Housing is critical for deliveries, as are proper hygienic conditions under the supervision of qualified health workers and proper care during delivery. In addition to postpartum care, postpartum care is an important part of reproductive health. The health of the mother and the newborn child is determined not only by how she feels during pregnancy and delivery, but also by the care she and the baby receive in the weeks after delivery. Postnatal check-up usually means that the mother is checked by a doctor for the first two months after giving birth [95, 96].

By preventing and treating reproductive health problems, reproductive health services promote reproductive health and well-being. Reproductive access to health refers to people who can reproduce and regulate their fertility; women who can safely go through pregnancy and childbirth; pregnancy success in terms of maternal and child survival; and couples who can have sex without risk of pregnancy or disease. Reduction of birth rate and child mortality are the main goals of India’s national public health agenda. In today’s world, contraception is the most important strategy for limiting rapid population growth. Fertility, infant mortality, and the acceptance of fertility treatments are influenced by several interrelated factors, such as age at marriage, education, and the economic status of women. The position of women in Indian society has long been considered inferior to their male counterparts. In rural areas, this can directly affect women’s health during pregnancy and childbirth. In rural India, maternal mortality accounts for 2% of all female deaths. In addition, women’s and children’s health issues were recognized as a priority. However, much work needs to be done to improve the quantity and quality of health care for women and children. Of course, those who live in the outskirts of the country require special attention [97-100].

Reproductive Health Needs

Many governments have expressed a desire to adopt a more holistic approach to reproductive health. To help national authorities systematically review reproductive health needs at national level, emphasis should be placed on adding innovative and participatory approaches to known epidemiological methods, where the process is usually led by experts and biomedical approaches and indicators. Women's health advocates, youth groups, and health care providers at the periphery and at the center should all be involved in identifying and prioritizing reproductive health needs and developing programmatic responses to those needs. A number of scenario analysis and needs assessment tools have already been developed in various areas of reproductive health, such as family planning and safe parenthood. However, in the context of a new approach to reproductive health, it is important to ensure that the evaluation and prioritization process reflects the concerns of people agreed at national and local levels, rather than the goals of agencies or funders. It is very important to reduce redundancies and develop tools adapted to the needs of individual countries. There are already some commonly used devices of this type. However, it is very important to ensure that the various tools currently available are interoperable and coherent. Similar problems exist in setting goals for generasan initiatives. Key issues should be identified according to their importance - prevalence, severity, public concern, public engagement, impact on families, impact on the community, and impact on development - and their feasibility - known activities, cost-effectiveness, availability of funding, human resources, and adequate equipment and supplies (Braeken & Rondinelli, 2012; Collumbien & Hawkes, 2000; Gyimah, Takyi, & Addai, 2006; Krause, Jones, & Purdin, 2000).

Reproductive Health Situation in Global Context

Women’s lives are changing dramatically across the board in a variety of settings. There is still a disconnect between women’s reproductive ambitions and their reproductive realities. For example, despite increasing contraceptive prevalence from 52 % in 1990 to 60 % in 2000 and 62 % in 2007, the unacceptably high demand for family planning in Sub-Saharan Africa remains unmet; one out of every four women who want to delay or stop child care does not use a family planning method. Adolescent pregnancy is still common in the world, with 52 births per 1,000 females aged 15-19 in 2007, down from 55 in 2000. The greatest youth birth rates in the world are found in Sub-Saharan Africa, followed by Latin America and the Caribbean. Furthermore, maternal mortality is still the leading cause of death among reproductive-age women in many nations. At least 1,600 women perish each day as a result of problems during pregnancy and childbirth. Every year, an estimated 358,000 women die as a result of complications during pregnancy or delivery, with 99 % of these deaths occurring in under developed countries only [26, 105-108]. The majority of these deaths occur in Asia and Sub-Saharan Africa, with around 90% occurring in other developing nations and less than 1% occurring in developed countries. Pregnancy or childbirth complications account for between 25% and 33% of all deaths among reproductive women in several developing countries. Between 1990 and 2008, the global maternal death rate declined by 34%, with an average yearly decrease of 2.3 %. This is significantly short of the MDG goal of a 5.5 % reduction in maternal mortality per year. In Africa, the use of reproductive health services for maternal care is also at an all-time low [109-112]. A professional health worker attended 65 % of deliveries between 2000 and 2006, whereas a third of women still have no skilled birth attendant. Only 48% of newborns in Africa were attended by a certified health worker. Similarly, pregnant women in Africa are less likely than in other regions of the world to visit antenatal care four times. Only 42% of women in Sub-Saharan Africa visit their doctor at least four times before giving birth. This glacial progress is becoming a source of concern for the international community. To effect change, international agencies and development partners are employing a variety of techniques and programmes. The ”H4” initiative, sponsored by the United Nations Population Fund (UNFPA), the United Nations Children’s Fund (UNICEF), and the World Bank, was launched in 2009 to provide immediate support to countries with the least developed maternal health systems. The UN Secretary-General spearheaded the development of a global strategy to enhance the health of women and children, with a focus on maternal and newborn health, with the goal of stimulating action on new and improved commitments and resources to improve the health of women and children. The strategy emphasizes the need to harmonize global commitments behind a number of agreed-upon priorities, including comprehensive family planning (advice, services, supplies); competent women and neonates care, including prenatal care, birth quality, complication emergency care, postnatal care, and basic newborn care; and safe abortions (when abortion is medically necessary) [113, 114]. The characteristics and ideas mentioned in this strategy are in accordance with and complement the WHO Global Strategy on Reproductive Health. Aside from death, the cost of illness is significant. Approximately 40% or more of pregnant women may experience acute obstetrical difficulties during pregnancy, childbirth, or the postpartum period, with an estimated 15% of pregnant women experiencing life-threatening complications. Most maternal deaths can be avoided if women have access to basic prenatal, delivery, and postpartum health care. This includes establishing health systems and establishing links between communities, health centres, and hospitals in order to provide treatment to women where they need it. Every year, 60 million babies are born around the world, with the help of family members, an untrained conventional parent, or no one at all. Only 53% of all deliveries in developing countries take place with the assistance of a trained birth attendant (a doctor or mid wife). As a result, having a trained healthcare professional is critical for making motherhood safer in developing countries. Furthermore, it is clear that only a small percentage of moms in developing countries, i.e. less than 30%, receive postpartum care. Because the early postpartum period is the most vulnerable time for maternal deaths, special attention must be provided to mothers in developing countries during this time. During pregnancy, millions of women in developing countries do not have access to competent care. Such care can help women and their families discover and manage existing illnesses, identify and treat complications early in life, provide information and advise on warning signs, recommend treatment when complications arise, and assist women and their families in preparing for childbirth. It is also evident that low rates of maternal health care utilization are driven by a variety of variables, including the distance of health facilities from the environment, expenditures, including direct charges, transit fees, drugs and supplies, and other demands on women’s time in poor nations. Women from developing countries lack decision-making power within the family, which has major ramifications for their maternal health due to inadequate service quality, notably in healthcare. As a result, countries around the world must have access to maternal health services in order to minimize maternal deaths, diseases and impairments, and infant fatalities by providing basic maternal care for all pregnancies, which should include a doctor or midwife at birth. Gender inequity and prejudice faced by women around the world must be addressed in order to improve women’s positions. Women’s reproductive and productive roles should be valued fully, especially in terms of contributing to the household and national economy. Attitudes towards the family and community that prevent women from receiving sufficient care during pregnancy and childbirth must be changed on a worldwide scale. Maternal mortality should be cut in half worldwide by the turn of the century in order to realize the goal of safe motherhood [114-117].

Reproductive Health Situation in India

After the International Conference on Population and Development in Cairo, Egypt in Sep 1994, and the Fourth World Conference on Women in Beijing, China in Sep 1995, women’s health in India became more important. Women’s health, empowerment, and reproductive rights were all major themes of both of these conferences. Leaving aside the importance of men’s health demands and conditions, the fact remains that women’s health is typically worse than men’s over the course of a lifetime. Furthermore, many health issues are more common in women than in males, and many health issues are unique to women/have a distinct impact on women than on men. Furthermore, when compared to their male counterparts, several environmental issues have a disproportionate impact on women. Gender inequality is the result of socialization and is perpetuated by it [30, 118-120]. In patriarchal societies like India, where males are seen as “superior” to women purely because of their sex, the gender divide is more pronounced. Being inferior to man entails having a lower position in all aspects of life, including health. Males and women have varied health demands at any one time, with women having more health care needs than men due to their biologically and culturally assigned roles. To elaborate, they are biologically responsible for reproduction; women alone are responsible for all of the issues and discomforts associated with pregnancy and birth. In India, women are expected to be subordinate to male household members and to work for the happiness and contentment of the latter. In addition, society expects them to play a critical role in providing informal health care to all family members. It is their responsibility to raise healthy children, teach those healthy habits, prepare and feed family members, and care for the young, sick, elderly, and disabled. She will have very little time after her duties are completed to spend on herself and consider her health needs. A woman is generally defined as a female who is at least fifteen years old. However, a woman’s health, as defined, is linked to her health-related experiences in her early years of life [121-123]. The complex sociocultural determinants of women’s health and nutrition have cumulative effects throughout a lifetime, according to India’s National Population Policy of 2000. Discrimination begins in the womb, with sex-based abortions, feticides, and the treatment of female children as second-class citizens from the minute they are born. Discrimination against girls leads to a decline in daycare and malnutrition, resulting in the girl child’s physical development being stunted. Diet in early adolescence is also said to be important for a woman’s health and, through her, for the health of her offspring. Social, cultural, and economic hurdles continue to prevent women from having adequate access to even current public health services in India,” according to the report. This handicap is harmful not only to women as individuals, but also to the health, general well-being, and development of the entire family, particularly children. This statement reflects the inherent character of society, which prevents women from receiving adequate health care, the inadequacy of accessible health care facilities, and the importance of women’s health in determining the health of other family members, particularly children. Despite the growing interest in women’s reproductive health in India, information on their situation remains limited. Adolescent marriage and fertility rates in India are alarmingly high. In India, unlike most other countries, adolescent fertility occurs mostly in the context of marriage. As a result of their early marriage, nearly half of them become pregnant by the age of 18, and nearly one in five by the age of 25. As a result, the size of adolescent fertility in India is significant: over half of all women aged 15-19 have had a pregnancy or given birth. Married adolescent women have reproductive health concerns because they are more likely than older women to have obstetrical complications. They are also subjected to a great deal of sexual violence. In terms of the unmarried population, sexual awareness and attitudes are still being studied insufficiently. Sexual awareness appears to be primarily superficial, and there is a lot of misinformation out there [124, 125]. This is exacerbated by parents and instructors’ unwillingness to share critical information. Peers, who may not be fully educated, or the media, which tends to focus on sexual and gender stereotypes or extremes, are possible sources of knowledge (or deception). Regardless of marital status, young females’ ability to make sexual and reproductive decisions is severely limited. Adolescent girls and women have limited options when it comes to marrying, having sexual encounters, having children, and seeking medical treatment. When it comes to sexual behaviour among adults and youth, the majority of Indian men and almost all Indian women have their first sexual encounter during marriage [126].

For example, there is fascinating information on the mapping of sexual contact places. A wide range of settings for sexual activities are known in both urban and rural areas, ranging from evident brothels to recreational areas, truck parking spaces, lodges and other small motels, and specific locations used by sex workers on various national roadways. One aspect of unsafe sexual intercourse is a woman’s inability to properly navigate pregnancy and childbirth in order to provide her child the best chance of survival [127, 128]. Maternal mortality and morbidity are quite high and, for the most part, preventable. Each year, 437 out of a million pregnant women die from pregnancy-related reasons, and between 4 and 5 million women suffer from poor health as a result of childbearing. The majority of maternal deaths and illnesses in India are preventable – conditions for which both knowledge and prevention techniques are accessible. Women’s reproductive health, on the other hand, is embedded in a larger sociocultural context that is usually ignored: the minimal study that has been done depicts a bleak image. Poor nutritional status and the resulting high levels of anaemia, early and repeated pregnancy, and delayed or limited health seeking associated to pregnancy in India are all factors that contribute to poor maternal outcomes. Abortion treatment is similarly limited for a large proportion of women who have an induced abortion; service providers are unskilled, and a significant minority of women has abortion-related complications. Women’s lack of authority to make health care decisions for themselves, seclusion practices that limit their mobility, socialization that causes them to downplay and bear their own health problems in silence, and a lack of control over the role they play in women’s health care decisions all limit maternal health. The limited mobility of women adds to the dangers of motherhood. Women’s access to health treatment is severely hampered by financial and opportunity costs. Families spend less time, effort, and money on health care for women and girls than they do for males on average. According to one of the most comprehensive abortion studies, 14 induced abortions per 100 live births occur in rural India. Abortion seekers are typically young (20-29 years old), married, and multifaceted, with teenagers and unmarried women being overrepresented. Furthermore, the majority of reasons for seeking abortion are to limit or space family size, revealing the country’s massive unmet contraception need. In a developing country like India, slowing population growth is a top priority [128, 129]. Family planning programmers are given special attention as a result of this. Maternity is the most important aspect of a woman’s reproductive health. In terms of maternal health, India is a step ahead of several other developing countries, with safe, regulated abortions, a primary health care system to care for rural women and children, and increasing literacy and awareness of the need for family planning. Each of these provides some level of protection to Indian women during their pregnancy. India provides low-income people with free family planning services [130]. In the fields of health and population, India has been at the forefront of various global movements. India has built up a sophisticated government infrastructure for maternal and child health, family planning, and other health services throughout the years. Lowering unwanted fertility, reproductive morbidity, and mortality costs are all part of meeting reproductive health needs. Poor women in India suffer severe reproductive burdens, a large portion of which is unrelated to pregnancy, and these reproductive disorders among women are nonvisible due to the “culture of silence” that surrounds them due to sexually transmitted reproductive infections. Many women have not received care and many reproductive health concerns have gone unaddressed since previous programmes viewed women as solely mothers [121, 131-133].

Conclusion

Good sexual and reproductive health is vital to women's overall health and well-being. It’s important to your ability to make decisions about your life, including when and if you want children. This not only includes the right to healthy and respectful interaction with one another. It also includes inclusive, safe and adequate health services, access to accurate information, effective and affordable birth control methods, and access to timely support for unplanned pregnancies. Sexual and reproductive health is not just about physical well-being. Different life stages involve specific sexually transmitted and sexually transmitted problems, including menstrual cramps, fertility, cervical exam, contraceptives, pregnancy, sexually transmitted infections, chronic diseases (e.g. endometriosis and polycystic ovary syndrome) and menopause. The practice of safe sex is particularly important for the sexual and reproductive health of sexually active women of all ages. Access to accurate, impartial, and up-to-date sexual and reproductive health information and services, such as vaccination against human papillomas, cervical cancer screening and sexually transmitted diseases, is also crucial. All of these can help women achieve optimal health and wellness. Optimal reproductive health can be achieved through access to sexual and reproductive health treatments, an appropriate lifestyle, and physical and mental health services.

Acknowledgement

Authors would like to thank all the authors whose work has been reviewed while preparing this manuscript.

Conflict of interest

None

Funding

None

Author Biographies

Irfat Ara, Research officer, Regional Research Institute of Unani Medicine, Srinagar, Jammu and Kashmir, India

 

 

Mohd Altaf Dar, Department of Pharmacology, CT Institute of Pharmaceutical Sciences, PTU, Jalandhar Punjab

 

 

References

Bartlett R, Yerbury JJ, Sluyter R. (2013). P2X7 Receptor Activation Induces Reactive Oxygen Species Formation and Cell Death in Murine EOC13 Microglia. Mediators Inflamm., doi: 10.1155/2013/271813

Lihite RJ, Lahkar M, Das S, Hazarika D, Kotni M, Maqbool M, Phukan S. A study on adverse drug reactions in a tertiary care hospital of Northeast India. Alexandria journal of medicine. 2017 Jul 11;53(2):151-6.

Bilbao P.S., Katz S, Boland R. (2012). Interaction of purinergic receptors with GPCRs, ion channels, tyrosine kinase and steroid hormone receptors orchestrates cell function. Purinergic Signal., 91-103

Borrelli F and Izzo AA (2000). The plant kingdom as a source of anti-ulcer remedies phytother Res;14:581-591.[Pubmed]

Rasool S, Maqbool M. An overview about Hedychium spicatum: a review. Journal of Drug Delivery and Therapeutics. 2019 Feb 15;9(1-s):476-80.

Brass D, Grably M, Bronstein-Sitton N, Gohar O, Meir A. (2012). Using antibodies against P2Y and P2X receptors in purinergic signaling research. Purinergic Signal., 61-79.

Maqbool M, Khan M, Mohammad M, Adesina MA, Fekadu G. Awareness about reproductive health in adolescents and youth: a review. Journal of Applied Pharmaceutical Sciences and Research. 2019 Oct 27:1-5.

Burnstock G. (2007a). Physiology and pathophysiology of purinergic neurotransmission. Physiol Rev., 87, 659-797.

Maqbool M, Gani I, Dar MA. Anti-diabetic effects of some medicinal plants in experimental animals: a review. Asian Journal of Pharmaceutical Research and Development. 2019 Feb 15;7(1):66-9.

Burnstock, G. (2007b). Purine and pyrimidine receptors. Cell Mol Life Sci., 1471-1483.

Maqbool M, Bekele F, Fekadu G. Treatment strategies against triple-negative breast cancer: an updated review. Breast Cancer: Targets and Therapy. 2022 Jan 1:15-24.

Burnstock, G., Knight, G.E., Greig, A.V. (2012). Purinergic signaling in healthy and diseased skin. J Invest Dermatol., 132, 526-546.

Zehravi M, Maqbool M, Ara I. Polycystic ovary syndrome and infertility: an update. International journal of adolescent medicine and health. 2021 Jul 22;34(2):1-9.

Burnstock G, Williams M. (2000). P2 purinergic receptors: modulation of cell function and therapeutic potential. J Pharmacol Exp Ther., 295, 862-869.

Chetan M, Prasad M and Nitin M, (2013). Role of Melatonin with Lansoprazole in Treating Peptic Ulcer in Rats. RGUHS J Pharm Sci; 3(2): 47-51.

Majeed A, Bashir R, Farooq S, Maqbool M. Preparation, characterization and applications of nanoemulsions: An insight. Journal of Drug Delivery and Therapeutics. 2019 Mar 15;9(2):520-7.

Compan V, Ulmann L, Stelmashenko O, Chemin J, Chaumont S, Rassendren F. (2012). P2X2 and P2X5 subunits define a new heteromeric receptor with P2X7-like properties. J Neurosci., 32, 4284-4296.

Mohd M, Maqbool M, Dar MA, Mushtaq I. Polycystic ovary syndrome, a modern epidemic: an overview. Journal of Drug Delivery and Therapeutics. 2019 May 15;9(3):641-4.

Compan V, Ulmann L, Stelmashenko O, Chemin J, Chaumont S, Rassendren F. (2012). P2X2 and P2X5 subunits define a new heteromeric receptor with P2X7-like properties. J Neurosci., 32, 4284-4296.

Zehravi M, Maqbool M, Ara I. Correlation between obesity, gestational diabetes mellitus, and pregnancy outcomes: an overview. International Journal of Adolescent Medicine and Health. 2021 Dec 1;33(6):339-45.

David YG (2014). History of Helicobacter pylori, duodenal ulcer, gastric ulcer and gastric cancer.world journal of Gastroenterology.

Maqbool R, Maqbool M, Zehravi M, Ara I. Menstrual distress in females of reproductive age: a literature review. International journal of adolescent medicine and health. 2021 Jul 22;34(2):11-7.

Dellal S.S., Hume R.I. (2012). Covalent modification of mutant rat P2X2 receptors with a thiol-reactive fluorophore allows channel activation by zinc or acidic pH without ATP. PLoS One., 7, e47147.

Malik JA, Maqbool M. COVID-19: An overview of current scenario. CELLMED. 2020;10(3):21-1.

Dong X, Smoll E.J, Lee J, Chow J.Y, Kim H.D, Insel P.A, Dong H. (2009). P2Y receptors mediate Ca2+ signaling in duodenocytes and contribute to duodenal mucosal bicarbonate secretion. Am J Physiol Gastrointest Liver Physiol., 296, G424-432.

Maqbool M, Rasool S, Dar MA, Bashir R, Khan M. Hepatotoxicity and Hepatoprotective agents: A Mini review. PharmaTutor. 2019 Sep 1;7(9):34-40.

Ecke D, Fischer B, Reiser G. (2008). Diastereoselectivity of the P2Y11 nucleotide receptor: mutational analysis. Br J Pharmacol., 155, 1250-1255.

Falk S, Uldall, M, Heegaard A.M. (2012). The role of purinergic receptors in cancer-induced bone pain. J Osteoporos., doi:10.1155/2012/758181.

Maqbool M, Fekadu G, Jiang X, Bekele F, Tolossa T, Turi E, Fetensa G, Fanta K. An up to date on clinical prospects and management of osteoarthritis. Annals of Medicine and Surgery. 2021 Dec 1;72:103077.

Farzaei MH, Rahimi R, Abbasabadin Z, Abdollahi M (2013). An Evidence- Basedreview on medical plants used for the treatment of peptic ulcer n traditional Iranian medicine. Int J Pharmacol;9:108-124.

Zehravi M, Maqbool M, Ara I. Depression and anxiety in women with polycystic ovarian syndrome: a literature survey. International Journal of Adolescent Medicine and Health. 2021 Dec 1;33(6):367-73.

Fievos LC (2008). Purinergic receptors and gastrointestinal secretomotor function.Journal of Purinergic Signalling.

Ara I, Maqbool M, Bukhari B, Ara N, Hajam TA. Present status, standardization and safety issues with herbal drugs. International Journal of Research in Pharmaceutical Sciences and Technology. 2020 May 18;1(3):95-101.

Fredholm B.B, IJzerman A.P, Jacobson K.A, Klotz K.N, Linden J (2001). International Union of Pharmacology. XXV. Nomenclature and classification of adenosine receptors. Pharmacol Rev., 53, 527-552.

Zehravi M, Maqbool M, Ara I. Healthy lifestyle and dietary approaches to treating polycystic ovary syndrome: a review. Open Health. 2022 Jan 1;3(1):60-5.

Gartland A, Orriss I.R, Rumney R.M, Bond A.P, Arnett T, Gallagher J.A. (2012). Purinergic signalling in osteoblasts. Front Biosci., 17, 16-29.

Maqbool M, Fekadu G, Dugassa D, Bekele F, Turi E, Simegnew D. The pattern of substance abuse in the psychiatry department of a tertiary care of Srinagar hospital, Jammu and Kashmir, India. Archives of Neuroscience. 2020 Oct 31;7(4).

Geoffery Burnstock. Purinergic signalling in the gastrointestinal tract and related organs in health and disease.2014;10(1):3-50.

Maqbool M, Dar AM, Rasool S, Khan M. Curious case of drug resistant malaria and artemisinin compounds in the modern era. Journal of Applied Pharmaceutical Sciences and Research. 2019 Jul 8:1-4.

Geoffrey Burnstock.(2006).Pathophysiology and Therapeutic Potential of Purinergic signelling. Pharmacological Reviews (ASPET) 2006.

Fekadu G, Bekele F, Bekele K, Hanbisa S, Belay G, Maqbool M. Drug Use Evaluation of Beta-Blockers in Medical Wards of Nedjo General Hospital, Western Ethiopia. Cardiovascular Therapeutics. 2020 Jun 1;2020.

Gerevich Z, Zadori Z, Mülle C, Wirkner K, Schröder W, Rubini P, Illes P. (2007). Metabotropic P2Y receptors inhibit P2X3 receptor-channels via G protein-dependent facilitation of their desensitization. Br J Pharmacol., 151, 226-236.

Maqbool M, Nasir N, Mustafa S. Polycystic in ovarian syndrome and its various treatment strategies. INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES. 2018 Sep 1;5(9):8470-8.

Ginsburg-Shmuel T, Haas M, Grbic D, Arguin G, Nadel Y. Gendron F.P, Reiser G, Fischer B(2012). UDP made a highly promising stable, potent, and selective P2Y6-receptor agonist upon introduction of a boranophosphate moiety. Bioorg Med Chem., 20, 5483-5495.

Gonzales E.B, Kawate T, Gouaux E. (2009). Pore architecture and ion sites in acid-sensing ion channels and P2X receptors. Nature. 460, 599-604.

Maqbool M, Naeem A, Aamer S. Diabetes Mellitus and Its Various Management Strategies in Practice. Indo American Journal of Pharmaceutical Sciences. 2018 Aug 1;5(8):8163-+.

Gudis K and Sakamoto C.(2005). The role of cyclooxygenase in gastric mucosal protection.” Digestive Diseases and Science; 5(1):S16-S23.

Maqbool M, Tariq S, Amjad S. Prescribing Practices in Pediatrics and Drug Utilization Studies Promoting Pediatric Health. Indo American Journal of Pharmaceutical Sciences. 2018 Aug 1;5(8):8070-6.

Hattori M, Gouaux E (2012). Molecular mechanism of ATP binding and ion channel activation in P2X receptors. Nature., 485, 207-212.

Dar MA, Maqbool M, Rasool S. Pharmaceutical wastes and their disposal practice in routine. Int J Inf Comput Sci. 2019 Apr;6:76-92.

Hirofumi Matsui, Osamu Shimokawa, Tsuyoshi Kaneko, Yumiko Nagano, Kanho Rai, and Ichinosuke Hyodo. The pathophysiology of non-steroidal anti-inflammatory drug (NSAID)-induced mucosal injuries in stomach and small intestine,.Journal of clinical biochemistry and nutrition.2011 Mar; 48(2):107-111.

Rasool S, Maqbool M, Joshi Y. Drug utilization studies among ENT patients in various clinical settings: A comprehensive review. Journal of Drug Delivery and Therapeutics. 2019 Feb 15;9(1-s):481-5.

Horckmans M, Robaye B, Léon-Gόmez E, Lantz N, Unger P, Dol-Gleize F, Clouet S,Cammarata D., Schaeffer, P., Savi, P., Gachet, C., Balligand, J.L., Dessy, C., Boeynaems, J.M., Communi D (2012). P2Y(4) nucleotide receptor: a novel actor in post-natal cardiac development. Angiogenesis., 15, 349-360.

Maqbool M. EVALUATION OF DRUG UTILIZATION PATTERN IN THE PEDIATRIC DEPARTMENT OF A TERTIARY CARE HOSPITAL IN SRINAGAR, JAMMU & KASHMIR, INDIA. Journal of Applied Pharmaceutical Sciences and Research. 2019:6-9.

Jacobson K.A, Balasubramanian R, Deflorian F, Gao Z.G. (2012). G protein-coupled adenosine (P1) and P2Y receptors: ligand design and receptor interactions. Purinergic Signal., 8, 419-436.

Maqbool M, Dar MA, Rasool S, Gani I, Khan M. Substance use disorder and availability of treatment options: an overview. Journal of research in health science. 2019;1:4-10.

James G, Mocormack, Marx, Boyett, Brain R, Jewell and Clive H.Department of Biochemistry and Physiology.Journal of Mol.cell(1988).

Maqbool M, Javed S, Bajwa AA. Assessment OF pain management IN postoperative cases using different scales and questionnaires. INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES. 2019 Jan 1;6(1):983-7.

Jiang B, Liu X, Chen H, Liu D, Kuang Y, Xing, B., Chen, Z. (2009). Ischemic postconditioning attenuates renal ischemic/reperfusion injury in mongrel dogs. Urology., 76, 1519.e1-1519.

Maqbool M, Arshad B, Liaquat S. PSYCHOTROPIC DRUG UTILISATION PATTERN CAN BE USEFUL IN MONITORING TREATMENT REGIMENS FOR MENTAL DISORDERS IN PSYCHIATRIC SETTINGS. INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES. 2018 Aug 1;5(8):7717-21.

Jiang R,Taly A, Grutter T (2013). Moving through the gate in ATP-activated P2X receptors. Trends Biochem Sci., 38, 20-29.

Maqbool M, Gani I. Utilization of Statins in Reducing Comorbidities of Diabetes Mellitus: A Systematic Review. Journal of Pharmacy Practice and Community Medicine. 2018;4(4).

John W. Mechanisms, prevention and clinical implications of nonsteroidal anti-inflammatory drug-enteropathy.world journal of gastroenterology.2013 march 28;1861-1867.

Ara I, Maqbool M, Zehravi M. Psychic consequences of infertility on couples: A short commentary. Open Health. 2022 Jan 1;3(1):114-9.

Kaur Amandeep, Singh Robin, Sharma Ramica and Kumar Sunil.(2012) A review on Etiology and Pathogenesis of Peptic Ulcer. International research journal of pharmacy.

Maqbool R, Maqbool M, Zehravi M, Ara I. Acute neurological conditions during pregnancy and their management: a review. International Journal of Adolescent Medicine and Health. 2021 Dec 1;33(6):357-66.

Kawate T, Michel J.C, Birdsong W.T, Gouaux E. (2009). Crystal structure of the ATP-gated P2X(4) ion channel in the closed state. Nature., 460, 592-598.

Maqbool M, Dugassa D, Fekadu G. Adverse Drug Reactions of Antiepileptic Drugs in the Neurology Department of a Tertiary Care Hospital, Srinagar, Jammu & Kashmir, India. Archives of Neuroscience. 2021 Apr 30;8(2).

Kudo F, Nishiguchi N, Nakano M., Ito K. (2012). Expression and function of the P2Y14 receptor in murine peritoneal macrophages. Hirosaki Med J., 63, 96-104.

Ara I, Maqbool M, Fekadu G, Hajam TA, Dar MA. Pharmaceutical significance of Nigella sativa L., a wonder herb. Journal of Applied Pharmaceutical Sciences and Research. 2020;3(4):04-13.

Kuo-Wei hsiang, Yee-Yung Ng, Ching-Liang Lu, Tseng-Shing Chen, Hsiao- Yi Lin, Jiing-Chyuan Luo, Jia-Min Wu, Han-Chieh Lin, Full-Youn Chang, and Shou-Dong Lee.(2010) Corticosteroids therapy and peptic ulcer disease in nephrotic syndrome patients.Journal of British Pharmacologica socity

Maqbool M, Zehravi M, Maqbool R, Ara I. An Overview about Treatment of Gestational Diabetes Mellitus: A Short Communication. CELLMED. 2021;11(3):12-.

Bashir R, Maqbool M, Ara I, Zehravi M. An In sight into Novel Drug Delivery System: In Situ Gels. CELLMED. 2021;11(1):6-1.

Fekadu G, Gamachu B, Mengie T, Maqbool M. Knowledge, attitude of health care professional’s towards clinical pharmacy services in Nedjo General Hospital, Western Ethiopia. International Journal. 2019 Jul;5(7):172.

Krawisz JE, Sharon P, Stenson WF. Quantitative assay for acute intestinal inflammation based on myeloperoxidase activity: assessment of inflammation in rat and hamster models. Gastroenterology. 1984 Dec 1;87(6):1344-50.

Mir PA, Mohi-Ud-Din R, Banday N, Maqbool M, Raza SN, Farooq S, Afzal S, Mir RH. Anticancer Potential of Thymoquinone: A Novel Bioactive Natural Compound from Nigella sativa L. Anti-Cancer Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry-Anti-Cancer Agents). 2022 Dec 1;22(20):3401-15.

Ara I, Maqbool M, Gani I. Reproductive Health of Women: Implications and attributes. International Journal of Current Research in Physiology and Pharmacology. 2022 Nov 28:8-18.

Maqbool M, Zehravi M. Neuroprotective Role of Polyphenols in Treatment of Neurological Disorders: A Review. Interventional Pain Medicine and Neuromodulation. 2021 Dec 31;1(1).

Ara I, Maqbool M. The curious case of Neuropathic Pain and its management: an overview. Open Health. 2022 Jan 1;3(1):145-54.

Ara I, Zehravi M, Maqbool M, Gani I. A Review of Recent Developments and Future Challenges in the Implementation of Universal Health Coverage Policy Framework in Some Countries. Journal of Pharmaceutical Research & Reports. SRC/JPRSR-131. DOI: doi. org/10.47363/JPRSR/2022 (3). 2022;127.

Landells LJ, Jensen MW, Orr LM, Spina D, 'Connor BJO, and C P Page. The role of adenosine receptors in the action of theophylline on human peripheral blood mononuclear cells from healthy and asthmatic subjects. British Journal of Pharmacology.(2000).Pubmed.

Zehravi M, Maqbool R, Maqbool M, Ara I. To Identify Patterns of Drug Usage among Patients Who Seek Care in Psychiatry Outpatient Department of a Tertiary Care Hospital in Srinagar, Jammu and Kashmir, India. Journal of Pharmaceutical Research International. 2021 Jun 10;33(31A):135-40.

Ara I, Maqbool M, Zehravi M, Gani I. Herbs Boosting Immunity in Covid-19: An Overview. Adv J Chem B. 2020;3(3):289-94.

Malik JA, Maqbool M, Hajam TA, Khan MA, Zehravi M. Comparison of different classes of drugs for Management of Acute Coronary Syndrome (ACS): A brief communication. CELLMED. 2021;11(2):7-1.

Maqbool M, Khan M. Hypertension and Pregnancy: an important issue. PharmaTutor. 2019 Aug 1;7(8):71-8.

Dar MA, Maqbool M, Javed S. Assessing Health-Related Quality Of Life (Qol) In Rheumatoid Arthritis. INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES. 2019 Jan 1;6(1):988-94.

Maqbool M, Shabbir W, Aamir S. Adverse Events Of Blood Transfusion And Blood Safety In Clinical Practice. Indo American Journal Of Pharmaceutical Sciences. 2018 Aug 1;5(8):8254-9.

Zehravi M, Maqbool M, Ara I. Teenage menstrual dysfunction: an overview. International Journal of Adolescent Medicine and Health. 2022 Sep 19.

Maqbool M, Dar MA, Rasool S, Bashir R, Khan M. Substance use Disorder: A Burning Issue. Lancet. 2019;375(9719):1014-28.

Zehravi M, Maqbool M, Ara I. An Update on Pain Control in Conservative Dentistry and Endodontics: A Review. The Indian Journal of Nutrition and Dietetics. 2022 Jan:114-25.

Maqbool M, Ikram U, Anwar A. Adverse Drug Reaction Monitoring And Occurrence In Drugs Used In Pulmonary Disorders. Indo American Journal Of Pharmaceutical Sciences. 2018 Aug 1;5(8):8060-5.

Ara I, Kalam MA, Maqbool M, Zehravi M. Phytochemical Standardization and Anti-Anxiety (Izterab-e-Nafsani) study of Aftimoon Hindi (Cuscuta reflexa Roxb.) on An Animal Model. CELLMED. 2021;11(3):14-.

Maqbool M, Zehravi M, Maqbool R, Ara I. Study of adverse drug reactions in pulmonary medicine department of a Tertiary care hospital, Srinagar, Jammu & Kashmir, India. CELLMED. 2021;11(2):8-1.

Khan M, Maqbool M. Maternal Health: An important issue. Journal of research in health science. 2019:1-2.

Dar MA, Maqbool M, Gani I, Ara I. Menstruation hygiene and related issues in adolescent girls: A brief commentary. International Journal of Current Research in Physiology and Pharmacology. 2023 Feb 11:1-5.

Zehravi M, Maqbool M, Ara I. An Overview about Safety Surveillance of Adverse Drug Reactions and Pharmacovigilance in India. The Indian Journal of Nutrition and Dietetics. 2021 Jul:408-18.

Ara I, Maqbool M, Gani I. Specificity and Personalized medicine: a novel approach to Cancer management. International Journal of Current Research in Physiology and Pharmacology. 2022 Dec 24:11-20.

Ara I, Maqbool M, Gani I. Neuroprotective Activity of Herbal Medicinal Products: A Review. International Journal of Current Research in Physiology and Pharmacology. 2022 Dec 23:1-0.

Rayan RA, Zafar I, Rajab H, Zubair MA, Maqbool M, Hussain S. Impact of IoT in Biomedical Applications Using Machine and Deep Learning. Machine Learning Algorithms for Signal and Image Processing. 2022 Dec 13:339-60.

Maqbool M, Ara I, Gani I. The Story of Polycystic Ovarian Syndrome: A Challenging Disorder with Numerous Consequences for Females of Reproductive Age. International Journal of Current Research in Physiology and Pharmacology. 2022 Nov 28:19-31.

Laine L, Takeuchi K, Tamawski A (2008). Gastric mucosal defense and cytoprotection:

Zehravi M, Maqbool M, Ara I. Unfolding the mystery of premenstrual syndrome (PMS): an overview. International Journal of Adolescent Medicine and Health. 2022 Sep 19.

Lalo U, Roberts J.A, Evans R.J (2011). Identification of human P2X1 receptor-interacting proteins reveals a role of the cytoskeleton in receptor regulation. J Biol Chem., 286, 30591-30599.

Bashir R, Maqbool M, Ara I, Zehravi M. An In sight into Novel Drug Delivery System: In Situ Gels. CELLMED. 2021;11(1):6-1.

Fekadu G, Bekele F, Bekele K, Hanbisa S, Belay G, Maqbool M. Drug Use Evaluation of Beta-Blockers in Medical Wards of Nedjo General Hospital, Western Ethiopia. Cardiovascular Therapeutics. 2020 Jun 1;2020.

Dar MA, Maqbool M, Rasool S, Gani I, Khan M. Haloperidol As An Antipsychotic: A Review. JOURNAL OF RESEARCH IN HEALTH SCIENCE.:31.

Maqbool M, Dar MA, Rasool S, Gani I, Khan M. Pharmacovigilance: A Program In Practice. JOURNAL OF RESEARCH IN HEALTH SCIENCE.:82.

Ludovico B, Eric S, Annemarthe G, Van DV, Rino R, Antonello C, et al . helicobacter Pylori cytotoxin-associated gene A subverts the apoptosis- stimuting protein of P53 AAPP2 tumor suppressor pathway of the host.2011; 1-6.

Magni G, Ceruti S. (2013). P2Y purinergic receptors: New targets for analgesic and antimigraine drugs. Biochem Pharmacol., 85, 466-477.

Majundar D, Bebb J, Atherton J. Helicobacter pylori infection and peptic ulcers. Med 2011; 39:154-161.

Mary Tolulope Olaleye, Ayodeji Emmannuel Amobonye, Kayode Komolafe, and Afolabi Clement Akinmoladun. Protective effects of Parinari curatellifolia flavonoids against acetaminophen-induced hepatic necrosis in rats.Sudi journal of biological science.2014 nov;21(5):486-492.

Michael Schieber and Navdeep S. Chandel.ROS Function in Redox Signaling and Oxidative Stress.2014 May;19:24(10)453-462.

Migalovich-Sheikhet H, Friedman S, Mankuta D, Levi-Schaffer F. (2012). Novel identified receptors on mast cells. Front Immunol., 3, 238-257.

Mohammad A, Al-Mofarreh, Ibrahim A and Al Mofleh. Esophageal ulceration complicating doxycycline therapy. World J Gastroenterol 2003;9 :609-611

Moore D, Chambers J, Waldvogel H, Faull R, Emson P (2000). Regional and cellular distribution of the P2Y(1) purinergic receptor in the human brain: striking neuronal localisation. J Comp Neurol., 421, 374-384.

Mundell S, Kelly E, Adenosine receptor desensitization and trafficking, Biochim Biophys Acta. 2011 May;1808(5):1319-1328.

Mustafa S.J, Ansari H.R, Abebe W (2009). P1 (adenosine) purinoceptor assays. Curr Protoc Pharmacol., 45, 4.7.1-4.7.13.

Muller N, Payan E, Lapicque F, Bannwarth B and Netter P. “Pharmacological aspects of chiral nonsteroidal anti-inflammatory drugs,” Fundamental and Clinical Pharmacology, vol. 4, no. 6, pp. 617–634, 1990.

North R.A, Jarvis M.F (2013). P2X Receptors as Drug Targets. Mol Pharmacol., 83, 759-769.

Notomi S, Hisatomi T, Murakami Y, Terasaki H, Sonoda S, Asato R, Takeda A, Ikeda Y., Enaida H, Sakamoto T, Ishibashi T (2013). Dynamic Increase in Extracellular ATP Accelerates Photoreceptor Cell Apoptosis via Ligation of P2RX7 in Subretinal Hemorrhage. PLoS One., 8, e53338. 544-547.

Olah M.E, Stiles G.L (2000). The role of receptor structure in determining adenosine receptor activity. Pharmacol Ther., 85, 55-75.

Orriss I.R, Key M.L, Brandao-Burch A, Patel J.J, Burnstock G, Arnett T.R (2012). The regulation of osteoblast function and bone mineralisation by extracellular nucleotides: The role of p2x receptors. Bone., 51, 389-400.

Osamu Handa, Yuji Naito, Akifumi Fukui, Tatsushi Omatsu and Toshikazu Yoshikawa. The impact of non-steroidal anti-inflammatory drugs on the small intestinal epithelium 2014;v 54(1):2-6. Journal of clinical biochemistry and nutrition.

P.Maity,K.Biswas,S.Ray,RK.Banerijee and Bandyopadayay U (2003) Smoking and the pathogenesis of Gastrroduodenal Ulcer recent mechanistic update.

Pankratov Y, Lalo U, Krishtal O.A, Verkhratsky A (2009). P2X receptors and synaptic plasticity. Neuroscience., 158, 137-148.

Ralevic V, Burnstock G. (1998). Receptors for purines and pyrimidines. Pharmacol Rev. 50, 413-492.

Rayah A, Kanellopoulos J.M., Di Virgilio F. (2012). P2 receptors and immunity. Microbes Infect., 14, 1254-1262.

Sabiu S, Wudil AM, Sunmonu TO (2015). Combined administration of Telfaira occidentalis and Vernonia amygdolina leaf powders amelio_rats garlic-induceed hepatotoxicity in wistar rats, pharmacology; 5(5):191-198.

Saheed sabiu, Taofeeq haruba,Taofik sunmomu,Emmanuel ajani and Abdulhakeem Balogun.Indomethacin-induced gastric ulceration in rats: Protective roles of Spondias mombin and Ficus exasperate.Toxology reports.2015

Sibel K, Burak S, Ahmet S, Mehmet A, Polat K, Ali A, Hasan D(2008). Effect of subclinical

Sibel K, Burak S, Ahmet S, Mehmet A, Polat K, Ali A, Hasan D. Effect of subclinical Helicobacter ylori inflectional Radiology 2008; 14:138-142.

Soll A and Graham D (2009). Peptic ulcer disease. In: Yamada T, editor. Text Book of Gastroenterology.5th ed.USA: Blackwell publication Ltd ;( 5):936-941.

Takao Masuda. Non-Enzymatic Functions of Retroviral Integrase: The Next Target for Novel Anti-HIV Drug Development.journal of microbial.2011 sep;2:210

Published

2023-08-27

How to Cite

Gani, I., Irfat Ara, & Altaf Dar, M. (2023). Reproductive Health of Women: a comprehensive review. International Journal of Current Research in Physiology and Pharmacology, 7(4s). Retrieved from https://sumathipublications.com/index.php/ijcrpp/article/view/469

Issue

Section

Review Articles

Most read articles by the same author(s)

1 2 > >>