International Journal of Current Research in Physiology and Pharmacology (IJCRPP) 2020-04-01T16:16:17-04:00 IJCRPP, Sumathi Publications Open Journal Systems <p><strong>eISSN: 2523-6709,&nbsp;</strong><strong>pISSN: 2523-6695.</strong></p> <p style="text-align: left;">(Logos are embedded with links)</p> <hr> <p style="text-align: left;"><a href=";refid=dcrecen" target="_blank" rel="noopener"><img src="/public/site/images/admin/base.png" alt=""></a> <a href=";publication=International+Journal+of+Clinical+and+Biomedical+Research&amp;publisher_str=Sumathi+Publications&amp;type=Journal+Article" target="_blank" rel="noopener"><img src="/public/site/images/admin/crossref1.png" alt=""></a> <a title="IJCRPP" href=";as_sdt=0%2C5&amp;;oq=site" target="_blank" rel="noopener"><img src="/public/site/images/admin/GoogleScholar1.png" alt=""></a> <a href=";qt=results_page" target="_blank" rel="noopener"><img src="/public/site/images/admin/logo_wcmasthead_en1.png" alt=""></a> <a href="" target="_blank" rel="noopener"><img src="/public/site/images/admin/pkp-index-301.png" alt=""></a> <a href=";la=en" target="_blank" rel="noopener"><img src="/public/site/images/admin/sherparomeo-home.jpg" alt=""></a></p> <hr> <p>International Journal of Current Research in Physiology and Pharmacology (IJCRPP) provides an outlet for research scientists in areas of Health Sciences. IJCRPP is open access, online &amp; Print, peer-reviewed international journal with a primary objective to provide research and applications related to Physiology, Pharmacology and Clinical Medicine.</p> <p>Submitted papers must be in technical English, suitable for scientific publication. All articles have to be original articles that have not been published elsewhere or are being considered for publication in other journals. All articles submitted will be peer-reviewed by experts. Receipt of the manuscript will be acknowledged by email. Every effort will be made to complete the review process within 3 weeks and communicated to the corresponding author. Papers should be submitted electronically on the journal's website. The Editorial Board will strive for the quality of the journal and will also index the journal in various indexing bodies and the information will be updated on the journal website from time to time.</p> <p>We welcome all your submissions.</p> <p>I hope you will consider IJCRPP for your next submission.</p> <p>If any further information is required please mail to:</p> <p><a href="" target="_blank" rel="noopener"></a> or</p> <p><a href="" target="_blank" rel="noopener"></a>.</p> <p>The journal accepts manuscripts in the following forms:</p> <ul> <li class="show">Original research articles</li> <li class="show">Reviews</li> <li class="show">Case reports</li> <li class="show">Short communications</li> <li class="show">Letters to editor</li> <li class="show">Discussion papers</li> <li class="show">Clinical Experience</li> <li class="show">Clinicopathological correlation</li> <li class="show">Book reviews</li> <li class="show">"How to do it" type articles describing new methods or procedures.</li> </ul> <p>Aim :</p> <ul> <li class="show">Our goal is to stimulate new research ideas and foster practical application from the research findings. The journal publishes original research, review articles, case reports of such high quality as to attract contributions from the relevant international communities.</li> </ul> <p>Critical Objective:</p> <ol> <li class="show">To maintain the highest standards of editorial integrity</li> <li class="show">To improve health, health care, and health education, internationally by elevating the quality of medical care, disease prevention, and research</li> <li class="show">To publish original, important, well-documented, peer-reviewed articles on basic medical sciences subject topics</li> <li class="show">To provide doctors with continuing education in basic&nbsp; science to support clinical decisions</li> <li class="show">To enable physicians to remain informed in multiple areas of basic medical science, including developments In the field of health education.</li> <li class="show">To achieve the highest level of ethical medical journalism and to produce a publication that is timely, credible, and enjoyable to read.</li> </ol> <p>Kind Regards,</p> <p>IJCRPP Editorial Team.</p> Photoperiod regulates the daily profiles of Tryptophan Hydroxylase-2 gene expression the raphe nuclei of rats 2020-04-01T16:16:15-04:00 Louay Labban Zeina Malek <p>Tryptophan hydroxylase-2 mRNA (TPH, the rate limiting enzyme in 5-HT synthesis) expression levels display circadian variations in the median and dorsal raphe nuclei. This circadian pattern is under the control of the suprachiasmatic nuclei (SCN), the master clock. Photoperiodic cue is encoded by the SCN which convey the seasonal message to target sites. In the present study, we have investigated the effect of photoperiodic changes on the serotonergic neurones of the raphe nuclei. We have assessed the daily expression of TPH2 mRNA in both median and dorsal raphe nuclei of rats housed either under long photoperiod (18&nbsp;h light/6&nbsp;h dark cycle, LP18:6) or short photoperiod (SP6:18). Our results demonstrate that under LP18:6, TPH2 mRNA levels display a progressive decrease during the dark period and a maximal expression is reported at the beginning of the light period. The expression pattern of TPH2 mRNA under SP6:18 remains unchanged during the dark period and increases significantly before the day/night transition. This latter expression pattern is in line with the daily profiles of TPH2 mRNA reported previously under standard lighting regimen (12&nbsp;h light/12&nbsp;h dark cycle). The present results suggest that TPH2 mRNA expression pattern within DR and MR is affected by photoperiod which might in turn affect TPH content and 5­HT release within the circadian structures, but also in all the serotonergic projection areas of the brain.</p> 2020-02-23T00:00:00-05:00 ##submission.copyrightStatement## Bone mineral density and its correlation with Vitamin D status in healthy adults of Manipur – A cross-sectional study 2020-04-01T16:16:16-04:00 Dr karthika M Prakash Chandra Bhardwaj Laimayum Amarnath Sharma W Kanan W Asoka Singh <p>The levels of vitamin D have an important effect on bone mass in young and old. Hypovitaminosis D adversely affects calcium metabolism, osteoblastic activity, matrix ossification, bone remodeling, and hence bone density. <br>Objective: The present study was conducted to determine the status of serum 25(OH)D and BMD of healthy adult men in Manipur and also to find out the relationship of 25(OH)D level with BMD. <br>Methods: A cross-sectional study was conducted in Department of Physiology in collaboration with the Department of Physical Medicine &amp; Rehabilitation, Regional Institute of Medical Sciences (RIMS), Imphal from October 2014 to September 2016. 100 Healthy adult males in Manipur in the age group 18-35years and ≥50years were included in the study after obtaining Ethical approval from the Research Ethics Board, RIMS, Imphal. The serum 25-OH vitamin D level was estimated by using an enzyme immunoassay (EIA) kit (IDS immunodiagnostic systems, United Kingdom). The BMD of lumbar spine was determined using enCORE – based X-ray bone densitometer (Lunar Prodigy advance, GE Medical Systems, USA) which is based on DEXA scan. <br>Results: The present study revealed that the majority of subjects with insufficiency of 25(OH)D had low bone mass, whereas all the subjects with 25(OH)D deficiency had BMD readings consistent with osteopenia or osteoporosis in both the age groups. This study also showed a positive correlation between BMD and 25(OH)D in most subjects, particularly in the groups with insufficiency or deficiency of 25(OH)D.<br>Conclusion: In conclusion, the study shows a positive relationship between the serum 25 (OH) D concentrations and BMD.</p> <p>Keywords: Serum 25(OH)D; Bone mineral density (BMD); Enzyme immunoassay (EIA).</p> 2020-02-23T00:00:00-05:00 ##submission.copyrightStatement## Pulmonary function tests in petrol pump workers exposed for three years to petrol/diesel fumes in Mathura District Uttar Pradesh 2020-04-01T16:16:17-04:00 DR.SATYANATH REDDY KODIDALA <p><strong>Background:</strong> Occupational and environmental exposure to petroleum refinery products poses a great threat to human health and petrol pump workers by virtue of their occupation are continuously exposed to petroleum gases and petroleum products. This community is generally neglected regarding their health.</p> <p><strong>Aims and objectives: </strong>This study aimed to assess and compare the Pulmonary functions of petrol pump workers with age-sex matched normal healthy individuals by using computerized Spirometry.</p> <p><strong>Materials and Methods: </strong>This is a cross-sectional study design in which 100 participants out of 50 petrol pump workers and 50 control group. Age, weight, height, ethnicity and socioeconomically matched subjects with minimum exposure of 3 years from different areas of Mathura district were recruited. Respiratory health of participants is ruled out by exclusion criteria. The Parameters TV, FVC (L), FEV<sub>1</sub>, FEV<sub>1</sub>/FVC, MVV and PEFR are measured by computerized spirometry (Helios).</p> <p><strong>Results: </strong>The Spirometry values were significantly reduced in participants working in the petrol pumps as compared to the controls. A significant decline in lung function parameters TV, FVC (L), FEV<sub>1</sub>, MVV, and PEFR were observed and no significance found in FEV<sub>1</sub> /FVC among Petrol Pump workers when compared to controls.</p> <p><strong>Conclusion</strong>: Subjects working in Petrol Pumps have significantly impaired lung functions. The lung function impairment pattern provides evidence in the favour of obstructive and restrictive lung disease and suggests improving control measures in petrol pumps.</p> 2020-02-23T00:00:00-05:00 ##submission.copyrightStatement## “SUPPLEMENTATION OF ZINC IN ACUTE AND CHRONIC HEAT STRESS ON ANTIOXIDANT CHANGES IN WISTAR ALBINO RATS” 2020-04-01T16:16:16-04:00 Antony Madhuri Bedadala Anthony David M <p><strong>ABSTRACT: </strong></p> <p><strong>Introduction:</strong> Heat stress is a major health burden with potential health out-comes. Oxidative stress is a metabolic dysfunction that carries oxidative damage of cells and tissues. Zinc is a co-factor against oxidative stress. <strong>Aim: </strong>The present study was done to evaluate the Supplementation of zinc in acute and chronic heat stress on antioxidant changes in wistar albino rats. <strong>Methodology</strong>: 36 Wistar albino rats were selected for the study. They were divided into 2 Groups. Group A was acutely and Group B was chronically heat stressed rats and both were zinc pretreated. The Enzymatic and Non enzyme activity in them were estimated.</p> <p><strong>Results:</strong> After acute and chronic heat stress, i) there was a significant increase (P &lt;0.001) in lipid peroxidation activity. ii) Enzymatic and Non-enzymatic antioxidants were reduced (P &lt; 0.001) iii) Rats pretreated with zinc showed a decrease (P&lt; 0.001) in lipid peroxidation and increase (P &lt; 0.001) in enzymatic antioxidants (P &lt; 0.001) and Non enzymatic antioxidants.</p> <p><strong>Key Words</strong>: antioxidants, heat stress, wistar albino rats</p> 2020-02-23T00:00:00-05:00 ##submission.copyrightStatement##