International Journal of Current Research in Physiology and Pharmacology <p><strong>eISSN: 2523-6709,&nbsp;</strong><strong>pISSN: 2523-6695.</strong></p> <p style="text-align: left;">(Logos are embedded with links)</p> <hr> <p style="text-align: left;"><a href=";refid=dcrecen" target="_blank" rel="noopener"><img src="/public/site/images/admin/base.png" alt=""></a> <a href=";publication=International+Journal+of+Clinical+and+Biomedical+Research&amp;publisher_str=Sumathi+Publications&amp;type=Journal+Article" target="_blank" rel="noopener"><img src="/public/site/images/admin/crossref1.png" alt=""></a> <a title="IJCRPP" href=";as_sdt=0%2C5&amp;;oq=site" target="_blank" rel="noopener"><img src="/public/site/images/admin/GoogleScholar1.png" alt=""></a> <a href=";qt=results_page" target="_blank" rel="noopener"><img src="/public/site/images/admin/logo_wcmasthead_en1.png" alt=""></a> <a href="" target="_blank" rel="noopener"><img src="/public/site/images/admin/pkp-index-301.png" alt=""></a> <a href=";la=en" target="_blank" rel="noopener"><img src="/public/site/images/admin/sherparomeo-home.jpg" alt=""></a></p> <hr> <p>International Journal of Current Research in Physiology and Pharmacology (IJCRPP) provides an outlet for research scientists in areas of Health Sciences. IJCRPP is open access, online &amp; Print, peer-reviewed international journal with a primary objective to provide research and applications related to Physiology, Pharmacology and Clinical Medicine.</p> <p>Submitted papers must be in technical English, suitable for scientific publication. All articles have to be original articles that have not been published elsewhere or are being considered for publication in other journals. All articles submitted will be peer-reviewed by experts. Receipt of the manuscript will be acknowledged by email. Every effort will be made to complete the review process within 3 weeks and communicated to the corresponding author. Papers should be submitted electronically on the journal's website. The Editorial Board will strive for the quality of the journal and will also index the journal in various indexing bodies and the information will be updated on the journal website from time to time.</p> <p>We welcome all your submissions.</p> <p>I hope you will consider IJCRPP for your next submission.</p> <p>If any further information is required please mail to: <a href="">Editor </a>or<a href=""> Journal Office</a>.</p> <p>The journal accepts manuscripts in the following forms:</p> <ul> <li class="show">Original research articles</li> <li class="show">Reviews</li> <li class="show">Case reports</li> <li class="show">Short communications</li> <li class="show">Letters to editor</li> <li class="show">Discussion papers</li> <li class="show">Clinical Experience</li> <li class="show">Clinicopathological correlation</li> <li class="show">Book reviews</li> <li class="show">"How to do it" type articles describing new methods or procedures.</li> </ul> <p>Aim :</p> <ul> <li class="show">Our goal is to stimulate new research ideas and foster practical application from the research findings. The journal publishes original research, review articles, case reports of such high quality as to attract contributions from the relevant international communities.</li> </ul> <p>Critical Objective:</p> <ol> <li class="show">To maintain the highest standards of editorial integrity</li> <li class="show">To improve health, health care, and health education, internationally by elevating the quality of medical care, disease prevention, and research</li> <li class="show">To publish original, important, well-documented, peer-reviewed articles on basic medical sciences subject topics</li> <li class="show">To provide doctors with continuing education in basic&nbsp; science to support clinical decisions</li> <li class="show">To enable physicians to remain informed in multiple areas of basic medical science, including developments In the field of health education.</li> <li class="show">To achieve the highest level of ethical medical journalism and to produce a publication that is timely, credible, and enjoyable to read.</li> </ol> <p>Kind Regards,</p> <p>IJCRPP Editorial Team.</p> Sumathi Publications en-US International Journal of Current Research in Physiology and Pharmacology 2523-6695 <p>The journal <strong>allows the author(s) to hold the copyright without restrictions and will retain publishing rights without restrictions</strong>.</p> <p>The submitted papers are assumed to contain no proprietary material unprotected by patent or patent application; responsibility for technical content and for protection of proprietary material rests solely with the author(s) and their organizations and is not the responsibility of the journal. The main (first/corresponding) author is responsible for ensuring that the article has been seen and approved by all the other authors. It is the responsibility of the author to obtain all necessary copyright release permissions for the use of any copyrighted materials in the manuscript prior to the submission.</p> <p><strong>What are my rights as an author?</strong><br>It is important to check the policy for the journal to which you are submitting or publishing to establish your rights as<br>Author. Journal's standard policies allow the following re-use rights:</p> <ul> <li class="show">The journal allows the author(s) to hold the copyright without restrictions.</li> <li class="show">The journal allows the author(s) to obtain publishing rights without restrictions.</li> <li class="show">You may do whatever you wish with the version of the article you submitted to the journal.</li> <li class="show">Once the article has been accepted for publication, you may post the accepted version of the article on your own personal website, your department's website or the repository of your institution without any restrictions.</li> <li class="show">You may not post the accepted version of the article in any repository other than those listed above (i.e. you may not deposit in the repository of another institution or a subject-matter repository) until 12 months after publication of the article in the journal.</li> <li class="show">You may use the published article for your own teaching needs or to supply on an individual basis to research colleagues, provided that such supply is not for commercial purposes.</li> </ul> Beyond the Surface: The Hidden Struggles of PCOS <p><strong>ABSTRACT</strong></p> <p>Polycystic Ovary Syndrome (PCOS) presents more than just physical symptoms; beneath the surface lie hidden struggles that profoundly impact those affected. While irregular periods and hormonal imbalances are recognized, the emotional toll is often overlooked. Elevated androgens can trigger mood disturbances, anxiety, and depression, creating a silent battle within. Fertility challenges add another layer of complexity. Conception difficulties, miscarriages, and fertility treatments expose individuals to a rollercoaster of hope and heartache. PCOS also inflicts a psychological burden, eroding self-esteem due to weight gain and societal beauty standards. Healthcare disparities and cultural stigmatization amplify the struggle, hindering proper diagnosis and treatment access. To address these hidden challenges, a holistic approach is imperative. Healthcare providers must acknowledge the emotional aspects, and awareness campaigns should dispel stigma. Empowering support networks can provide solace, while education fosters better self-care. By uncovering and addressing these concealed battles, we pave the way for comprehensive care, improved well-being, and a deeper understanding of the complex reality that PCOS entails.</p> <p><strong>Keywords:</strong> PCOS, fertility, miscarriage, infertility.</p> Abrar Bashir Malik Zulfkar Qadrie Mohd Altaf Dar Copyright (c) 2023 Abrar Bashir Malik, Zulfkar Qadrie, Mohd Altaf Dar 2023-09-30 2023-09-30 10 23 Unchain Your Heart: Battling Coronary Artery Disease <p><strong>ABSTRACT</strong></p> <p>Coronary Artery Disease (CAD) remains a significant contributor to illness and mortality on a global scale. It is characterized by the gradual narrowing of coronary arteries due to the formation of atherosclerotic plaques, leading to a disruption in the blood supply to the heart muscle. This often results in ischemic events such as angina and heart attacks. This summary offers a concise overview of CAD, concentrating on its causes, risk factors, clinical presentation, and contemporary methods of treatment. The development of CAD involves a complex interaction of genetic predisposition, traditional risk factors (such as hypertension and abnormal lipid levels), and lifestyle factors. Despite its subtle beginnings, CAD can show itself through symptoms like angina, breathlessness, or silent ischemia. Early detection is crucial and can be aided by stress tests, coronary angiography, and non-invasive imaging techniques. Approaches to managing CAD encompass adjustments to one's lifestyle, pharmacological interventions, and invasive procedures. Lifestyle changes involve dietary improvements, physical activity, and smoking cessation, all of which have been proven to slow down the progression of CAD. Medications like antiplatelets, statins, and beta-blockers target risk factors and alleviate symptoms. Invasive treatments such as percutaneous coronary intervention (PCI) and coronary artery bypass grafting (CABG) restore blood flow, leading to better quality of life and increased survival rates. In conclusion, the widespread occurrence of CAD and its clinical implications highlight the importance of proactive prevention and evidence-based treatment. Advances in diagnostic methods and therapeutic approaches continue to shape the management of CAD, leading to improved outcomes and instilling optimism in the fight against this challenging cardiovascular condition.</p> <p><strong>Keywords:</strong> Heart, Coronary artery, Lifestyle, medications.</p> Abrar Bashir Malik Mashooq Ahmad Mir Mohd Altaf Dar Copyright (c) 2023 Abrar Bashir Malik, Mashooq Ahmad Mir, Mohd Altaf Dar 2023-09-30 2023-09-30 24 38 Navigating the Heart's Highway: Effective Management of Coronary Artery Disease <p data-id="_paragraph-5"><strong data-id="_bold-2">ABSTRACT</strong></p> <p data-id="_paragraph-6">Coronary artery disease (CAD) management involves a multifaceted approach aimed at reducing risk factors, improving symptoms, and preventing disease progression. Lifestyle modifications form the foundation of CAD management, emphasizing a healthy diet, regular exercise, smoking cessation, weight management, and stress reduction. Adopting these changes can effectively control blood pressure, lipid levels, and overall cardiovascular health. Medical therapies play a vital role in CAD management. Antiplatelet drugs like aspirin reduce the risk of blood clot formation, while lipid-lowering agents, particularly statins, help lower cholesterol levels and slow atherosclerosis development. Beta-blockers and ACE inhibitors/ARBs are commonly prescribed to control heart rate, blood pressure, and improve heart function. In cases of severe CAD, interventional procedures may be necessary. Percutaneous coronary intervention (PCI) involves inserting a stent into the narrowed artery to restore blood flow, while coronary artery bypass grafting (CABG) creates new pathways to bypass blocked arteries. Secondary prevention is essential for patients with a history of CAD. Regular follow-ups, adherence to prescribed medications, and participation in cardiac rehabilitation programs can significantly reduce the risk of future cardiac events. Efforts to manage CAD extend beyond the individual level. Public health initiatives and community awareness campaigns promote healthy lifestyle choices to prevent CAD on a broader scale. In conclusion, the management of coronary artery disease demands a comprehensive approach, incorporating lifestyle changes, medical therapies, interventional procedures, and secondary prevention strategies. By addressing CAD from multiple angles, healthcare professionals can effectively reduce its impact, improve patient outcomes, and enhance the overall cardiovascular health of affected individuals.</p> <p data-id="_paragraph-7"><strong data-id="_bold-3">Keywords:</strong> Heart, Coronary artery, Lifestyle, medications.</p> Mashooq Ahmad Mir Abrar Bashir Malik Mohd Altaf Dar Copyright (c) 2023 Mashooq Ahmad Mir, Abrar Bashir Malik, Mohd Altaf Dar 2023-09-30 2023-09-30 39 49 Aspirin Unveiled: Shielding Hearts from Coronary Artery Disease <p><strong>ABSTRACT</strong></p> <p>In the realm of cardiovascular protection, aspirin emerges as a potent sentinel against Coronary Artery Disease (CAD). Beyond its well-known pain-relief properties, aspirin's remarkable antiplatelet action takes center stage. By inhibiting platelet aggregation through COX-1 enzyme suppression, aspirin mitigates the formation of arterial thrombi, crucial in averting heart attacks and strokes. Aspirin's role spans both secondary and selective primary prevention. In secondary prevention, it stands as a stalwart defense, substantially lowering the risk of recurrent cardiovascular events. In primary prevention, its application is tailored to high-risk individuals, although careful consideration of bleeding risks is paramount. Yet, aspirin is not immune to scrutiny. Concerns include potential bleeding complications, gastric irritation, and drug interactions. In this evolving landscape, its application aligns with emerging guidelines, fine-tuning its role in CAD management. "Aspirin Unveiled: Shielding Hearts from Coronary Artery Disease" encapsulates aspirin's pivotal stance in cardiovascular protection. As a guardian of platelet activity, it plays a crucial role in curbing CAD's impact, symbolizing hope in the battle for heart health.</p> <p><strong>Keywords: </strong>Coronary artery disease, Heart, Management.</p> Abrar Bashir Malik Mashooq Ahmad Mir Zulfkar Qadrie Mohd Altaf Dar Copyright (c) 2023 Abrar Bashir Malik, Mashooq Ahmad Mir, Zulfkar Qadrie, Mohd Altaf Dar 2023-09-30 2023-09-30 50 60 Epilepsy and Neuroinflammation: Unraveling the Complex Connection <p><strong>ABSTRACT</strong></p> <p>Epilepsy, a neurological disorder characterized by recurring seizures, has long been a subject of scientific exploration. Recent research has unveiled an intriguing link between epilepsy and neuroinflammation, the brain's immune response to injury or infection. This connection has shed light on how inflammation contributes to the development and progression of epilepsy. Neuroinflammation appears to play a pivotal role in epileptogenesis—the process of normal brain tissue becoming hyperexcitable and prone to seizures. Immune cells like microglia and astrocytes release inflammatory molecules that disrupt neurotransmitter balance, promoting neuronal hyperexcitability. This heightened excitability sets the stage for seizure generation. The interaction between neuroinflammation and seizures is bidirectional. Seizures can trigger immune responses, releasing pro-inflammatory molecules. Conversely, inflammation lowers the seizure threshold, making individuals more susceptible to seizures. Mechanisms underlying this relationship include blood-brain barrier dysfunction, altered synaptic plasticity, and an imbalance between excitatory and inhibitory signaling. Understanding these mechanisms has therapeutic implications. Targeting neuroinflammatory pathways could suppress inflammation and reduce seizure frequency. Neuroprotective agents may prevent inflammation-induced damage and halt epileptogenesis. Immunomodulatory treatments might restore the balance between pro- and anti-inflammatory responses, regulating neuroinflammation and reducing seizure susceptibility. The intricate interplay between epilepsy and neuroinflammation is a captivating field of study. Unraveling this complex connection offers insights into the underlying mechanisms of epilepsy, potentially leading to novel therapeutic approaches. By addressing both neurological and inflammatory aspects, researchers aim to improve epilepsy management and enhance the lives of those affected by this condition.</p> <p><strong>Keywords:</strong> Epilepsy, neuroinflammation, seizures, inflammation.</p> Mashooq Ahmad Mir Abrar Bashir Malik Zulfkar Qadrie Mohd Altaf Dar Copyright (c) 2023 Mashooq Ahmad Mir, Abrar Bashir Malik, Zulfkar Qadrie, Mohd Altaf Dar 2023-09-30 2023-09-30 3 9 Editorial on Nipah Virus: A Looming Threat Ambadasu Bharatha Kandamaran Krishnamurthy Copyright (c) 2023 Ambadasu Bharatha, Kandamaran Krishnamurthy 2023-09-30 2023-09-30 1 2