International Journal of Current Research in Physiology and Pharmacology (IJCRPP) <p><strong>eISSN: 2523-6709,&nbsp;</strong><strong>pISSN: 2523-6695.</strong></p> <p style="text-align: left;">(Logos are embedded with links)</p> <hr> <p style="text-align: left;"><a href=";refid=dcrecen" target="_blank" rel="noopener"><img src="/public/site/images/admin/base.png" alt=""></a> <a href=";publication=International+Journal+of+Clinical+and+Biomedical+Research&amp;publisher_str=Sumathi+Publications&amp;type=Journal+Article" target="_blank" rel="noopener"><img src="/public/site/images/admin/crossref1.png" alt=""></a> <a href=";as_sdt=0%2C5&amp;q=2523-6695&amp;btnG=" target="_blank" rel="noopener"><img src="/public/site/images/admin/GoogleScholar1.png" alt=""></a> <a href=";qt=results_page" target="_blank" rel="noopener"><img src="/public/site/images/admin/logo_wcmasthead_en1.png" alt=""></a> <a href="" target="_blank" rel="noopener"><img src="/public/site/images/admin/pkp-index-301.png" alt=""></a> <a href=";la=en" target="_blank" rel="noopener"><img src="/public/site/images/admin/sherparomeo-home.jpg" alt=""></a></p> <hr> <p>International Journal of Current Research in Physiology and Pharmacology (IJCRPP) provides an outlet for research scientists in areas of Health Sciences. IJCRPP is an open access, online &amp; Print, peer reviewed international journal with a primary objective to provide research and applications related to Physiology, Pharmacology and Clinical Medicine.</p> <p>Submitted papers must be in technical English, suitable for scientific publication. All articles have to be original articles that have not been published elsewhere or are being considered for publication in other journals. All articles submitted will beÂ&nbsp;peer reviewed by experts. Receipt of the manuscript will be acknowledged by email. Every effort will be made to complete the review process within 3 weeks and communicated to the corresponding author. Papers should be submitted electronically on the journal's website. The Editorial board will strive for the quality of the journal and will also index the journal in various indexing bodies and the information will be updated on the journal website from time to time.</p> <p>We welcome all your submissions.</p> <p>I hope you will consider IJCRPP for your next submission.</p> <p>If any further information is required please mail to:</p> <p><a href="" target="_blank" rel="noopener"></a> or</p> <p><a href="" target="_blank" rel="noopener"></a>.</p> <p>The journal accepts manuscripts in the following forms:</p> <ul> <li class="show">Original research articles</li> <li class="show">Reviews</li> <li class="show">Case reports</li> <li class="show">Short communications</li> <li class="show">Letters to editor</li> <li class="show">Discussion papers</li> <li class="show">Clinical Experience</li> <li class="show">Clinico-pathological correlation</li> <li class="show">Book reviews</li> <li class="show">"How to do it" type articles describing new methods or procedures.</li> </ul> <p>Aim :</p> <ul> <li class="show">Our goal is to stimulate new research ideas and foster practical application from the research findings. The journal publishes original research, review articles, case reports of such high quality as to attract contributions from the relevant international communities.</li> </ul> <p>Critical Objective:</p> <ol> <li class="show">To maintain the highest standards of editorial integrity</li> <li class="show">To improve health, health care, and health education, internationally by elevating the quality of medical care, disease prevention, and research</li> <li class="show">To publish original, important, well-documented, peer-reviewed articles on basic medical sciences subject topics</li> <li class="show">To provide doctors with continuing education in basic&nbsp; science to support clinical decisions</li> <li class="show">To enable physicians to remain informed in multiple areas of basic medical science, including developments In the field of health education.</li> <li class="show">To achieve the highest level of ethical medical journalism and to produce a publication that is timely, credible, and enjoyable to read.</li> </ol> <p>Kind Regards,</p> <p>IJCRPP Editorial Team.</p> Sumathi Publications en-US International Journal of Current Research in Physiology and Pharmacology (IJCRPP) 2523-6695 <p>The journal <strong>allows the author(s) to hold the copyright without restrictions and will retain publishing rights without restrictions</strong>.</p> <p>The submitted papers are assumed to contain no proprietary material unprotected by patent or patent application; responsibility for technical content and for protection of proprietary material rests solely with the author(s) and their organizations and is not the responsibility of the journal. The main (first/corresponding) author is responsible for ensuring that the article has been seen and approved by all the other authors. It is the responsibility of the author to obtain all necessary copyright release permissions for the use of any copyrighted materials in the manuscript prior to the submission.</p> <p><strong>What are my rights as author?</strong><br>It is important to check the policy for the journal to which you are submitting or publishing to establish your rights as<br>Author. Journal's standard policies allow the following re-use rights:</p> <ul> <li class="show">The journal allow the author(s) to hold the copyright without restrictions.</li> <li class="show">The journal allow the author(s) to obtain publishing rights without restrictions.</li> <li class="show">You may do whatever you wish with the version of the article you submitted to the journal.</li> <li class="show">Once the article has been accepted for publication, you may post the accepted version of the article on your own personal website, your department's website or the repository of your institution without any restrictions.</li> <li class="show">You may not post the accepted version of the article in any repository other than those listed above (i.e. you may not deposit in the repository of another institution or a subject-matter repository) until 12 months after publication of the article in the journal.</li> <li class="show">You may use the published article for your own teaching needs or to supply on an individual basis to research colleagues, provided that such supply is not for commercial purposes.</li> </ul> Effects of α, β momorcharin extract of momordica charantia in intracellular free calcium on cancer cell lines. <p><span lang="EN-IN">The&nbsp;<em>Momordica charantia&nbsp;</em>L., (family: <em>Cucurbitaceae</em>) is a scientific name of the plant and its fruit. It is also known by other names, for instance in the USA it is known as Bitter gourd or balsam pear while its referred to as the African cucumber in many African countries.&nbsp;</span><span lang="EN-IN">This study was specifically designed to investigate the cellular mechanisms whereby alpha</span><span lang="EN-IN">, beta momorcharin an extract of&nbsp;<em>M. charantia</em>can induce cell death measuring the elevation in intracellular free calcium concentrations in three different cancer cell lines&nbsp;</span><span lang="EN-IN">1321N1,&nbsp;</span><span lang="EN-IN">Gos-3 and U-87.</span><strong><span lang="EN-IN">&nbsp;</span></strong><span lang="EN-IN">The results show that incubation of the three cancer cell lines 1321N1,&nbsp;</span><span lang="EN-IN">Gos-3 and U-87 with&nbsp; α, β momorcharin can result in significant (p &lt; 0.05) time-dependent increases in [Ca<sup>2+</sup>]<sub>i&nbsp;</sub>in all three cancer cell lines compared to control (untreated) cells. Maximal increases in [Ca<sup>2+</sup>]<sub>i</sub><span style="font-size: 11.6667px;">&nbsp;</span>was attained after 420 min of incubation.In control (untreated cell lines), [Ca<sup>2+</sup>]<sub>i&nbsp;</sub>remained more or less stable in both cell lines after 420 min.<sub>&nbsp;</sub>The results also show that the increase in [Ca<sup>2+</sup>]<sub>i&nbsp;</sub>in Gos-3 cell line was much more pronounced following incubation with α, β momorcharin compared to 1321N1 and U-87 cell line. The results show that incubation of the three cancer cell lines with&nbsp; momorcharin can result in significant (p &lt; 0.05) time-dependent increases in [Ca<sup>2+</sup>]<sub>i&nbsp;</sub>in all three cancer cell lines compared to control (untreated) cells. Maximal increases in [Ca<sup>2+</sup>]<sub>i&nbsp;</sub>was attained after 420 min of incubation. In control (untreated cell lines), [Ca<sup>2+</sup>]<sub>i&nbsp;</sub>remained more or less stable in all three cell lines after 420 min.<sub>&nbsp;</sub></span><span lang="EN-IN">These results clearly show that&nbsp; α, β</span><span lang="EN-IN">&nbsp;momorcharin extract of&nbsp;</span><span lang="EN-IN"><em>M. charantia&nbsp;</em>is exerting its anti- cancer effect via an insult to the mitochondria resulting in apoptosis, calcium overloading and subsequently, cell death.</span></p> GUNASEKAR MANOHARAN ##submission.copyrightStatement## 2019-03-03 2019-03-03 1 4 10.31878/ijcrpp.2019.31.1 Conceptual, sociological and materialistic view of innovation-translation dynamics in medicine: The need and directions for a novel multi-pronged initiative <p>The recent decades have witnessed overwhelming advancements in medical technologies and the quality of healthcare. A vast majority of the advancements which are capable of revolutionising healthcare still remain dormant within laboratories which is certainly due to the tardive translation and assimilation of these innovations. Innovation-translation is explained by an over-simplified linear model which provides the users with just two option- either to adopt or not. The translation of medical innovation is a cyclical and dynamic process which includes the conception of novel ideas, generation of proof of concept, adoption, post-adoption analysis and emergence of new innovations. Conceptual factors like principle, validity, contextual appropriateness and performance; sociological factors like political climate, professional involvement, interdisciplinary interaction and investment policies; and materialistic factors like resource availability, affordability and apt human resource management are the chief determinants of innovation translation. Loose knit configuration of national policies favour innovation translation than close knit configuration. India suffers from lack of drive for local innovation, lack of succinct aptitude, inadequate local investment and lack of efficient regulation. Innovation studies expose the determinants of successful and failed innovations. Ensuring a favourable political and financial environment that provides systematic innovation assessment, evaluation and regulation, valid operational guidelines, encourage local innovation, and promote intellectual aptitude can drive further innovation. Competitively promoting sustaining and disruptive innovation will enable remarkable advancements. Post-adoption analysis and feedback and Precision medicine are significant tools. Efforts should be made to introduce and ensure meticulous innovation surveillance.</p> <p>Keywords: Innovation-translation dynamics; Cyclic dynamic model; Innovation surveillance; Regulation.</p> Ebinesh A Bharath NL Harshitha J Naik ##submission.copyrightStatement## 2019-03-03 2019-03-03 5 11 10.31878/ijcrpp.2019.31.2