International Journal of Current Research in Physiology and Pharmacology <p><strong>eISSN: 2523-6709,&nbsp;</strong><strong>pISSN: 2523-6695.</strong></p> <p style="text-align: left;">(Logos are embedded with links)</p> <hr> <p style="text-align: left;"><a href=";refid=dcrecen" target="_blank" rel="noopener"><img src="/public/site/images/admin/base.png" alt=""></a> <a href=";publication=International+Journal+of+Clinical+and+Biomedical+Research&amp;publisher_str=Sumathi+Publications&amp;type=Journal+Article" target="_blank" rel="noopener"><img src="/public/site/images/admin/crossref1.png" alt=""></a> <a title="IJCRPP" href=";as_sdt=0%2C5&amp;;oq=site" target="_blank" rel="noopener"><img src="/public/site/images/admin/GoogleScholar1.png" alt=""></a> <a href=";qt=results_page" target="_blank" rel="noopener"><img src="/public/site/images/admin/logo_wcmasthead_en1.png" alt=""></a> <a href="" target="_blank" rel="noopener"><img src="/public/site/images/admin/pkp-index-301.png" alt=""></a> <a href=";la=en" target="_blank" rel="noopener"><img src="/public/site/images/admin/sherparomeo-home.jpg" alt=""></a></p> <hr> <p>International Journal of Current Research in Physiology and Pharmacology (IJCRPP) provides an outlet for research scientists in areas of Health Sciences. IJCRPP is open access, online &amp; Print, peer-reviewed international journal with a primary objective to provide research and applications related to Physiology, Pharmacology and Clinical Medicine.</p> <p>Submitted papers must be in technical English, suitable for scientific publication. All articles have to be original articles that have not been published elsewhere or are being considered for publication in other journals. All articles submitted will be peer-reviewed by experts. Receipt of the manuscript will be acknowledged by email. Every effort will be made to complete the review process within 3 weeks and communicated to the corresponding author. Papers should be submitted electronically on the journal's website. The Editorial Board will strive for the quality of the journal and will also index the journal in various indexing bodies and the information will be updated on the journal website from time to time.</p> <p>We welcome all your submissions.</p> <p>I hope you will consider IJCRPP for your next submission.</p> <p>If any further information is required please mail to: <a href="">Editor </a>or<a href=""> Journal Office</a>.</p> <p>The journal accepts manuscripts in the following forms:</p> <ul> <li class="show">Original research articles</li> <li class="show">Reviews</li> <li class="show">Case reports</li> <li class="show">Short communications</li> <li class="show">Letters to editor</li> <li class="show">Discussion papers</li> <li class="show">Clinical Experience</li> <li class="show">Clinicopathological correlation</li> <li class="show">Book reviews</li> <li class="show">"How to do it" type articles describing new methods or procedures.</li> </ul> <p>Aim :</p> <ul> <li class="show">Our goal is to stimulate new research ideas and foster practical application from the research findings. The journal publishes original research, review articles, case reports of such high quality as to attract contributions from the relevant international communities.</li> </ul> <p>Critical Objective:</p> <ol> <li class="show">To maintain the highest standards of editorial integrity</li> <li class="show">To improve health, health care, and health education, internationally by elevating the quality of medical care, disease prevention, and research</li> <li class="show">To publish original, important, well-documented, peer-reviewed articles on basic medical sciences subject topics</li> <li class="show">To provide doctors with continuing education in basic&nbsp; science to support clinical decisions</li> <li class="show">To enable physicians to remain informed in multiple areas of basic medical science, including developments In the field of health education.</li> <li class="show">To achieve the highest level of ethical medical journalism and to produce a publication that is timely, credible, and enjoyable to read.</li> </ol> <p>Kind Regards,</p> <p>IJCRPP Editorial Team.</p> en-US <p>The journal <strong>allows the author(s) to hold the copyright without restrictions and will retain publishing rights without restrictions</strong>.</p> <p>The submitted papers are assumed to contain no proprietary material unprotected by patent or patent application; responsibility for technical content and for protection of proprietary material rests solely with the author(s) and their organizations and is not the responsibility of the journal. The main (first/corresponding) author is responsible for ensuring that the article has been seen and approved by all the other authors. It is the responsibility of the author to obtain all necessary copyright release permissions for the use of any copyrighted materials in the manuscript prior to the submission.</p> <p><strong>What are my rights as an author?</strong><br>It is important to check the policy for the journal to which you are submitting or publishing to establish your rights as<br>Author. Journal's standard policies allow the following re-use rights:</p> <ul> <li class="show">The journal allows the author(s) to hold the copyright without restrictions.</li> <li class="show">The journal allows the author(s) to obtain publishing rights without restrictions.</li> <li class="show">You may do whatever you wish with the version of the article you submitted to the journal.</li> <li class="show">Once the article has been accepted for publication, you may post the accepted version of the article on your own personal website, your department's website or the repository of your institution without any restrictions.</li> <li class="show">You may not post the accepted version of the article in any repository other than those listed above (i.e. you may not deposit in the repository of another institution or a subject-matter repository) until 12 months after publication of the article in the journal.</li> <li class="show">You may use the published article for your own teaching needs or to supply on an individual basis to research colleagues, provided that such supply is not for commercial purposes.</li> </ul> (IJCRPP, Sumathi Publications) (Journal office) Sun, 10 Dec 2023 06:50:19 +0000 OJS 60 Postural changes in blood pressure and heart rate among healthy young adults in a Ghanaian university <p><strong>Introduction: </strong>There are contradictory and inconsistent reports on the effects of different body postures on measured blood pressure and heart rate. This relationship has not been previously tested in the Ghanaian population.</p> <p><strong>Aim of the study: </strong>The overall aim of the study was to investigate the effects of different body positions on blood pressure and heart rate among Ghanaian healthy young adults.</p> <p><strong>Methods: </strong>Blood pressure and heart rate were measured subsequently in eight different positions on the left arm in the following non-randomized order: (i) sitting with arm flexed at the elbow and supported at the heart level on the chair, (ii) sitting with legs crossed, (iii) standing, (iv) supine, (v) right lateral recumbent, (vi) left lateral recumbent, (vii) prone, an (viii) bent with hands holding knees with face pointing to the ground. The repeated measures for ANOVA were used to compare the means in different positions. Statistically significance was pegged at p-value &lt; 0.05.</p> <p><strong>Results: </strong>The mean systolic and diastolic blood pressures were lowest in the right lateral recumbent position as compared to the other positions whiles the bent position recorded both the highest systolic and diastolic blood pressures and heart rate.</p> <p><strong>Conclusion: </strong>The highest mean blood pressure and heart rates are found in the bent position as compared to other body postures. The lowest mean systolic and diastolic blood pressures are found in the right lateral recumbent posture.</p> <p><strong>Keywords: </strong>Posture, blood pressure, heart rate, Ghanaian, Adults</p> Perez Quartey, Ernest Halm, Obed Yeboah-Arhin Copyright (c) 2023 Perez Quartey, Ernest Halm, Obed Yeboah-Arhin Sun, 10 Dec 2023 00:00:00 +0000 To study different types of epileptic seizures and their treatment in a Superspeciality Hospital Jalandhar, Punjab, India <p><strong>Introduction: </strong>Epilepsy is a neurological disorder characterized by recurrent and unpredictable seizures, which are abnormal bursts of electrical activity in the brain. These seizures can vary in intensity and manifestation, causing a range of physical and cognitive effects. Epilepsy affects people of all ages and backgrounds, with over 65 million individuals’ worldwide living with the condition. Seizures in epilepsy can manifest in different ways, from convulsive jerking motions to momentary lapses in awareness. They can be triggered by various factors, including sleep deprivation, stress, flashing lights, or underlying brain conditions. Diagnosing epilepsy involves a comprehensive evaluation of a person's medical history, symptoms, and often electroencephalogram (EEG) tests to monitor brain activity. Treatment options for epilepsy aim to reduce the frequency and severity of seizures. This can include medication, which helps stabilize brain activity and prevent excessive electrical discharges. <strong>Objective: </strong>The objective of this study was to study different types of epileptic seizures and their treatment in a Superspeciality Hospital Jalandhar, Punjab, India. <strong>Methodology:</strong> This was a prospective, observational study investigating 90 patients with epileptic seizure in NASA AND HUB SUPERSPECIALITY HOSPITAL (NHS) located in Jalandhar Punjab for over a period of 4 months. This study revealed the treatment strategies used by physicians and correlation among treatment, control and complications of Epilepsy within the Indian context. This study eventually helped to develop person-centered care and facilitate public health agencies to invest appropriate resources in the management of Epilepsy in the health care system. <strong>Results:</strong> While studying about the gender wise distribution of patients, It was found that total number of patients at Nasa And Hub Superspeciality Hospital were 90, in which male patients were 60 accounting for 66.7% of study population, whereas the female patients were 30 accounting for 33.3% of total study population. <strong>Conclusion: </strong>The aim of the study was carried out to get the better awareness regarding epileptic seizures and to focus on the correct diagnosis for better treatment. The study focus on the most number of patients admitted at hospital with different types of seizures and the antiepileptic drugs to treat seizures. The study was done to differentiate between various groups of patients with epilepsy, of either sex or age.</p> <p><strong>Keywords: </strong>Epilepsy, Phenytoin, valproate.</p> Mashooq Ahmad Mir, Abrar Bashir Malik, Zulfkar Qadrie, Mohd Altaf Dar Copyright (c) 2023 Mashooq Ahmad Mir, Abrar Bashir Malik, Zulfkar Qadrie, Mohd Altaf Dar Sun, 10 Dec 2023 00:00:00 +0000 A need of the hour: pharmacovigilance in healthcare setting – nothing less than safety <p><strong>Introduction</strong>: Pharmacovigilance (PV) is crucial to identify, managing, and reporting adverse drug reactions (ADRs) in the healthcare sector. Young healthcare professionals (HCPs) play an essential role in the PV system. <strong>Objective</strong>: This study aimed to assess awareness, understand the causes of underreporting, and find solutions to encourage ADR reporting among young HCPs. <strong>Methods</strong>: This prevalidated, questionnaire-based, cross-sectional study aimed to evaluate the knowledge, attitude, perception, and strategies to improve PV reporting among 152 young HCP interns at a teaching hospital in India. The study was conducted in January 2023 and approved by the ethics committee. The responses were analysed using a Microsoft Excel worksheet<strong>. Results</strong> In a study of 152 interns, 97.3% agreed that pharmacovigilance (PV) may assist patients, but only 56% had experienced adverse drug reactions (ADRs) in practise. Only 40.5% chose email reporting, and 65.8% did not have a nearby ADR Monitoring Centre (AMC). More over half (53%) thought ADRs should only be reported to an AMC. Training sessions were underutilised, with only 28.6% attending PVPI training. The difficulty in identifying the causal substance, as well as a lack of incentives, were important reasons for underreporting. Continuing medical education/workshops were mentioned by 96% of young HCPs as a way to encourage reporting. <strong>Conclusion:</strong> According to the study, while young HCPs are aware of PV, there is a need for more training and incentives to enhance ADR reporting. Encouragement of National Pharmacovigilance Week and the availability of neighbouring AMCs could further aid raise PV awareness.</p> <p><strong data-id="_bold-18">Keywords:</strong> Adverse drug reactions (ADR), PVPI, AMC, CME</p> Preeti Shanbhag, Satish S , Mr.Ramdas Bhat, A R Shabaraya Copyright (c) 2023 Preeti Shanbhag, Satish S , Mr.Ramdas Bhat, A R Shabaraya Sun, 10 Dec 2023 00:00:00 +0000 Adverse Reactions Caused by Antiepileptic Medications in Real-World Medical Settings <p>Epilepsy is a relatively common condition characterized by a tendency for recurrent seizures, which is due to the disturbance of spread of electrical discharge of the cortical neurons. Up to 80% of people with epilepsy are able to control their condition with anti epileptic drugs (AEDs). The growing number of newly approved drugs for various illnesses coupled with the complex treatment options have contributed to the increased risk of adverse drug reactions (ADRs). AEDs have a narrow therapeutic index with wide spectrum of ADRs. 10-30% of epileptic patients discontinue their initially prescribed AEDs due to ADRs. These ADRs can be the cause of non-adherence and subjective distress. The newer generation AEDs have reduced adverse events, fewer drug interactions if any and thus improved safety. Comparison of adverse effects in patients taking AEDs with adverse events in control groups is helpful; however, data from controlled studies are often lacking for most AEDs. Because of these limitations, the clinician must adopt a preventative and early detection approach based on some general principles. This review outlines various adverse reactions related to the use of Anti-epileptic drugs.</p> <p><strong>Keywords</strong>: adverse reactions, antiepileptic drugs, carbamazepine, phenytoin</p> Mashooq Ahmad Mir, Abrar Bashir Malik, Zulfkar Qadrie, Mohd Altaf Dar Copyright (c) 2023 Mashooq Ahmad Mir, Abrar Bashir Malik, Zulfkar Qadrie, Mohd Altaf Dar Sun, 10 Dec 2023 00:00:00 +0000