The Impact of Hormones and Migraine Headache in Women's Life – A short communication
Keywords:
Migraine, hormones, Estrogen, central nervous system, menopauseAbstract
Migraine headaches occur more frequently in women than in men. Women are more likely to get migraines for longer periods of time than males. It is a chronic neurological condition that affects between 10% and 12% of the population. Women experienced headaches more frequently, for a longer duration, and with greater severity than males. The hypothalamic hypophyseal-ovarian axis regulates women's reproductive cycles through the production of oestrogen and progesterone. Variations in these hormone levels regulate and control every aspect of life, from menstruation to pregnancy, puerperium, and menopause. The luteal or ovulatory phase is divided into the follicular or proliferative phase and the luteal or ovulatory phase. Migraine is classified into two basic types: migraine without aura and migraine with aura. Menstruation is the second most common migraine trigger after stress. During perimenopause, between 8% and 13% of migraine sufferers reported a new beginning of symptoms. Migraine can be treated successfully at any age, whether acute or preventative. Nonsteroidal anti-inflammatory medicines (NSAIDs), antiepileptic drugs topiramate and valproate, beta-blockers such as propranolol, and tricyclic antidepressants amitriptyline and nortriptyline are the most frequently suggested treatments. Migraine is a frequent occurrence in women's life. The primary cause of migraine in women is the variation of sex hormone levels during menstruation. Migraines are caused by a woman's hormone levels fluctuating throughout time.
Keywords: Migraine, hormones, Estrogen, central nervous system, menopause
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S. Boubacar, L. Seck, H. Assadeck, I. Diallo, O. Cisse, Migraine in women: What Specificities? A review, J Women's Health Care 6(349) (2017) 2167-0420.1000349.
G. Terwindt, M. Ferrari, M. Tijhuis, S. Groenen, H. Picavet, L. Launer, The impact of migraine on quality of life in the general population: the GEM study, Neurology 55(5) (2000) 624-629.
L. Ligthart, M.M. Gerrits, D.I. Boomsma, B.W. Penninx, Anxiety and depression are associated with migraine and pain in general: an investigation of the interrelationships, The journal of pain 14(4) (2013) 363-370.
G. Serafini, M. Pompili, M. Innamorati, G. Gentile, M. Borro, D.A. Lamis, N. Lala, A. Negro, M. Simmaco, P. Girardi, Gene variants with suicidal risk in a sample of subjects with chronic migraine and affective temperamental dysregulation, Eur Rev Med Pharmacol Sci 16(10) (2012) 1389-1398.
R.B. Lipton, M.E. Bigal, Migraine: epidemiology, impact, and risk factors for progression, Headache: The Journal of Head and Face Pain 45 (2005) S3-S13.
M. Maqbool, M. Khan, M. Mohammad, M.A. Adesina, G. Fekadu, Awareness about reproductive health in adolescents and youth: a review, Journal of Applied Pharmaceutical Sciences and Research (2019) 1-5.
R.J. Lihite, M. Lahkar, S. Das, D. Hazarika, M. Kotni, M. Maqbool, S. Phukan, A study on adverse drug reactions in a tertiary care hospital of Northeast India, Alexandria journal of medicine 53(2) (2017) 151-156.
M. Maqbool, M.A. Dar, I. Gani, S.A. Mir, M. Khan, Herbal medicines as an alternative source of therapy: a review, World J Pharm Pharm Sci 3 (2019) 374-80.
S. Rasool, M. Maqbool, An overview about Hedychium spicatum: a review, Journal of Drug Delivery and Therapeutics 9(1-s) (2019) 476-480.
I. Ara, M. Maqbool, G. Fekadu, T.A. Hajam, M.A. Dar, Pharmaceutical significance of Nigella sativa L., a wonder herb, Journal of Applied Pharmaceutical Sciences and Research 3(4) (2020) 04-13.
A.I. Scher, W.F. Stewart, R.B. Lipton, Migraine and headache: a meta-analytic approach, Epidemiology of pain 159 (1999) 170.
B.K. Rasmussen, Migraine and tension-type headache in a general population: precipitating factors, female hormones, sleep pattern and relation to lifestyle, Pain 53(1) (1993) 65-72.
S. Wang, J. Fuh, K. Juang, S. Lu, Rising prevalence of migraine in Taiwanese adolescents aged 13-15 years, Cephalalgia 25(6) (2005) 433-438.
I. Ara, M. Maqbool, I. Gani, Neuroprotective Activity of Herbal Medicinal Products: A Review, International Journal of Current Research in Physiology and Pharmacology (2022) 1-10.
M. Maqbool, F. Bekele, G. Fekadu, Treatment strategies against triple-negative breast cancer: an updated review, Breast Cancer: Targets and Therapy (2022) 15-24.
M. Zehravi, M. Maqbool, I. Ara, Polycystic ovary syndrome and infertility: an update, International journal of adolescent medicine and health 34(2) (2021) 1-9.
M. Maqbool, M.A. Dar, I. Gani, S.A. Mir, Animal models in diabetes mellitus: an overview, Journal of Drug Delivery and Therapeutics 9(1-s) (2019) 472-475.
A. Majeed, R. Bashir, S. Farooq, M. Maqbool, Preparation, characterization and applications of nanoemulsions: An insight, Journal of Drug Delivery and Therapeutics 9(2) (2019) 520-527.
M. Maqbool, G. Fekadu, D. Dugassa, F. Bekele, E. Turi, D. Simegnew, The pattern of substance abuse in the psychiatry Department of a Tertiary Care of Srinagar Hospital, Jammu and Kashmir, India, Archives of Neuroscience 7(4) (2020).
D.C. Buse, E.W. Loder, J.A. Gorman, W.F. Stewart, M.L. Reed, K.M. Fanning, D. Serrano, R.B. Lipton, Sex Differences in the Prevalence, Symptoms, and Associated Features of Migraine, Probable Migraine and Other Severe H eadache: Results of the A merican Migraine Prevalence and Prevention (AMPP) Study, Headache: The Journal of Head and Face Pain 53(8) (2013) 1278-1299.
M. Zehravi, M. Maqbool, I. Ara, Correlation between obesity, gestational diabetes mellitus, and pregnancy outcomes: an overview, International Journal of Adolescent Medicine and Health 33(6) (2021) 339-345.
R. Maqbool, M. Maqbool, M. Zehravi, I. Ara, Menstrual distress in females of reproductive age: a literature review, International journal of adolescent medicine and health 34(2) (2021) 11-17.
J.A. Malik, M. Maqbool, COVID-19: An overview of current scenario, CELLMED 10(3) (2020) 21.1-21.8.
M. Maqbool, S. Rasool, M.A. Dar, R. Bashir, M. Khan, Hepatotoxicity and Hepatoprotective agents: A Mini review, PharmaTutor 7(9) (2019) 34-40.
M. Murtaza, M. Kisat, H. Daniel, A.B. Sonawalla, Classification and clinical features of headache disorders in Pakistan: a retrospective review of clinical data, PloS one 4(6) (2009) e5827.
J. Olesen, The international classification of headache disorders, Headache: The Journal of Head and Face Pain 48(5) (2008) 691-693.
W.F. Stewart, A. Shechter, R.B. Lipton, Migraine heterogeneity. Disability, pain intensity, and attack frequency and duration, Neurology 44(6 Suppl 4) (1994) S24-39.
R.B. Lipton, J. Pan, Is migraine a progressive brain disease?, Jama 291(4) (2004) 493-494.
N. Maleki, C. Linnman, J. Brawn, R. Burstein, L. Becerra, D. Borsook, Her versus his migraine: multiple sex differences in brain function and structure, Brain 135(8) (2012) 2546-2559.
E.T. Richey, K.A. Kooi, R. Waggoner, Visually evoked responses in migraine, Electroencephalography and clinical neurophysiology 21(1) (1966) 23-27.
M. Maqbool, M.A. Dar, I. Gani, S.A. Mir, M. Khan, A.U. Bhat, Maternal health and nutrition in pregnancy: an insight, World Journal of Pharmacy and Pharmaceutical Sciences 8(3) (2019) 450-459.
M. Maqbool, G. Fekadu, X. Jiang, F. Bekele, T. Tolossa, E. Turi, G. Fetensa, K. Fanta, An up to date on clinical prospects and management of osteoarthritis, Annals of Medicine and Surgery 72 (2021) 103077.
I. Ara, M. Maqbool, B. Bukhari, N. Ara, T.A. Hajam, Present status, standardization and safety issues with herbal drugs, International Journal of Research in Pharmaceutical Sciences and Technology 1(3) (2020) 95-101.
M. Zehravi, M. Maqbool, I. Ara, Healthy lifestyle and dietary approaches to treating polycystic ovary syndrome: a review, Open Health 3(1) (2022) 60-65.
M. Mohd, M. Maqbool, M.A. Dar, I. Mushtaq, Polycystic Ovary Syndrome, a modern epidemic: An overview, Journal of Drug Delivery and Therapeutics 9(3) (2019) 641-644.
L. Cupini, M. Matteis, E. Troisi, P. Calabresi, G. Bernardi, M. Silvestrini, Sex‐hormone‐related events in migrainous females. A clinical comparative study between migraine with aura and migraine without aura, Cephalalgia 15(2) (1995) 140-144.
C. Wöber-Bingöl, C. Wöber, A. Karwautz, A. Auterith, M. Serim, K. Zebenholzer, K. Aydinkoc, C. Kienbacher, C. Wanner, P. Wessely, Clinical features of migraine: a cross-sectional study in patients aged three to sixty-nine, Cephalalgia 24(1) (2004) 12-17.
K. Weitzel, J. Strickland, K. Smith, J. Goode, Gender-specific issues in the treatment of migraine, The journal of gender-specific medicine: JGSM: the official journal of the Partnership for Women's Health at Columbia 4(1) (2001) 64-74.
V. Faria, N. Erpelding, A. Lebel, A. Johnson, R. Wolff, D. Fair, R. Burstein, L. Becerra, D. Borsook, The migraine brain in transition: girls vs boys, Pain 156(11) (2015) 2212-2221.
N. Breslau, G.C. Davis, L.R. Schultz, E.L. Paterson, Migraine and major depression: a longitudinal study, Headache: The Journal of Head and Face Pain 34(7) (1994) 387-393.
M. Maqbool, A.M. Dar, S. Rasool, M. Khan, Curious case of drug resistant malaria and artemisinin compounds in the modern era, Journal of Applied Pharmaceutical Sciences and Research (2019) 1-4.
G. Fekadu, F. Bekele, K. Bekele, S. Hanbisa, G. Belay, M. Maqbool, Drug Use Evaluation of Beta-Blockers in Medical Wards of Nedjo General Hospital, Western Ethiopia, Cardiovascular Therapeutics 2020 (2020).
Y. Guo, S. Xu, S. Nie, M. Han, Y. Zhang, J. Chen, X. Hou, Y. Hong, X. Liu, Female versus male migraine: an event-related potential study of visual neurocognitive processing, The journal of headache and pain 20(1) (2019) 1-11.
M. Maqbool, I. Gani, M.A. Dar, Anti-diabetic effects of some medicinal plants in experimental animals: a review, Asian Journal of Pharmaceutical Research and Development 7(1) (2019) 66-69.
R. Smith, Impact of migraine on the family, Headache: The Journal of Head and Face Pain 38(6) (1998) 423-426.
K.R. Merikangas, Contributions of epidemiology to our understanding of migraine, Headache: The Journal of Head and Face Pain 53(2) (2013) 230-246.
Y. Celik, G. Ekuklu, B. Tokuç, U. Utku, Migraine prevalence and some related factors in Turkey, Headache: The Journal of Head and Face Pain 45(1) (2005) 32-36.
M. Maqbool, N. Nasir, S. Mustafa, Polycystic in ovarian syndrome and its various treatment strategies, INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES 5(9) (2018) 8470-8478.
M. Maqbool, M. Dar, S. Rasool, S. Mir, A. Bhat, M. Khan, Clinical pharmacy practice in health care system: A review, Eur J Pharm Med Res 6(4) (2019) 630-633.
E.A. MacGregor, Classification of perimenstrual headache: clinical relevance, Current pain and headache reports 16(5) (2012) 452-460.
E.W. Loder, Menstrual migraine: pathophysiology, diagnosis, and impact, Headache: The Journal of Head and Face Pain 46 (2006) S56-S61.
M.B. Russell, B.K. Rasmussen, P. Thorvaldsen, J. Olesen, Prevalence and sex-ratio of the subtypes of migraine, International journal of epidemiology 24(3) (1995) 612-618.
M. Russell, B. Rasmussen, K. Fenger, J. Olesen, Migraine without aura and migraine with aura are distinct clinical entities: a study of four hundred and eighty-four male and female migraineurs from the general population, Cephalalgia 16(4) (1996) 239-245.
L. Ligthart, D.I. Boomsma, N.G. Martin, J.H. Stubbe, D.R. Nyholt, Migraine with aura and migraine without aura are not distinct entities: further evidence from a large Dutch population study, Twin Research and Human Genetics 9(1) (2006) 54-63.
M. Maqbool, A. Naeem, S. Aamer, Diabetes Mellitus and Its Various Management Strategies in Practice, Indo American Journal of Pharmaceutical Sciences 5(8) (2018) 8163-+.
M. Maqbool, S. Tariq, S. Amjad, Prescribing Practices in Pediatrics and Drug Utilization Studies Promoting Pediatric Health, Indo American Journal of Pharmaceutical Sciences 5(8) (2018) 8070-8076.
M.A. Dar, M. Maqbool, S. Rasool, Pharmaceutical wastes and their disposal practice in routine, Int J Inf Comput Sci 6 (2019) 76-92.
S. Rasool, M. Maqbool, Y. Joshi, Drug utilization studies among ENT patients in various clinical settings: A comprehensive review, Journal of Drug Delivery and Therapeutics 9(1-s) (2019) 481-485.
M. Maqbool, EVALUATION OF DRUG UTILIZATION PATTERN IN THE PEDIATRIC DEPARTMENT OF A TERTIARY CARE HOSPITAL IN SRINAGAR, JAMMU & KASHMIR, INDIA, Journal of Applied Pharmaceutical Sciences and Research (2019) 6-9.
M. Maqbool, S. Javed, A.A. Bajwa, Assessment OF pain management IN postoperative cases using different scales and questionnaires, INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES 6(1) (2019) 983-987.
M. Maqbool, B. Arshad, S. Liaquat, PSYCHOTROPIC DRUG UTILISATION PATTERN CAN BE USEFUL IN MONITORING TREATMENT REGIMENS FOR MENTAL DISORDERS IN PSYCHIATRIC SETTINGS, INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES 5(8) (2018) 7717-7721.
K.G. Vetvik, E.A. MacGregor, C. Lundqvist, M.B. Russell, Prevalence of menstrual migraine: a population-based study, Cephalalgia 34(4) (2014) 280-288.
E.A. MacGregor, Menstrual migraine: therapeutic approaches, Therapeutic advances in neurological disorders 2(5) (2009) 327-336.
M. Maqbool, I. Gani, Utilization of Statins in Reducing Comorbidities of Diabetes Mellitus: A Systematic Review, Journal of Pharmacy Practice and Community Medicine 4(4) (2018).
I. Ara, M. Maqbool, M. Zehravi, Psychic consequences of infertility on couples: A short commentary, Open Health 3(1) (2022) 114-119.
M. Maqbool, M. Zehravi, R. Maqbool, I. Ara, An Overview about Treatment of Gestational Diabetes Mellitus: A Short Communication, CELLMED 11(3) (2021) 12.1-12.5.
R. Bashir, M. Maqbool, I. Ara, M. Zehravi, An In sight into Novel Drug Delivery System: In Situ Gels, CELLMED 11(1) (2021) 6.1-6.7.
G. Fekadu, B. Gamachu, T. Mengie, M. Maqbool, Knowledge, attitude of health care professional’s towards clinical pharmacy services in Nedjo General Hospital, Western Ethiopia, International Journal 5(7) (2019) 172.
I. Ara, M. Maqbool, I. Gani, Reproductive Health of Women: Implications and attributes, International Journal of Current Research in Physiology and Pharmacology (2022) 8-18.
J.M. Pavlović, The impact of midlife on migraine in women: summary of current views, Women's midlife health 6(1) (2020) 1-7.
M. Khan, M. Maqbool, Hypertension and Pregnancy: an important issue ABOUT AUTHORS, Hypertension 17 (2019) 0.
I. Ara, M. Zehravi, M. Maqbool, I. Gani, A Review of Recent Developments and Future Challenges in the Implementation of Universal Health Coverage Policy Framework in Some Countries, Journal of Pharmaceutical Research & Reports. SRC/JPRSR-131. DOI: doi. org/10.47363/JPRSR/2022 (3) 127 (2022).
M. Zehravi, R. Maqbool, M. Maqbool, I. Ara, To Identify Patterns of Drug Usage among Patients Who Seek Care in Psychiatry Outpatient Department of a Tertiary Care Hospital in Srinagar, Jammu and Kashmir, India, Journal of Pharmaceutical Research International 33(31A) (2021) 135-140.
I. Ara, M. Maqbool, M. Zehravi, I. Gani, Herbs Boosting Immunity in Covid-19: An Overview, Adv J Chem B 3(3) (2020) 289-94.
N.C. Chai, B.L. Peterlin, A.H. Calhoun, Migraine and estrogen, Current opinion in neurology 27(3) (2014) 315.
V.T. Martin, M. Behbehani, Ovarian hormones and migraine headache: understanding mechanisms and pathogenesis—part I, Headache: The Journal of Head and Face Pain 46(1) (2006) 3-23.
J.A. Malik, M. Maqbool, T.A. Hajam, M.A. Khan, M. Zehravi, Comparison of different classes of drugs for Management of Acute Coronary Syndrome (ACS): A brief communication, CELLMED 11(2) (2021) 7.1-7.5.
M. Maqbool, M. Khan, Hypertension and Pregnancy: an important issue, PharmaTutor 7(8) (2019) 71-78.
M.A. Dar, M. Maqbool, S. Javed, Assessing Health-Related Quality Of Life (Qol) In Rheumatoid Arthritis, INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES 6(1) (2019) 988-994.
M. Maqbool, W. Shabbir, S. Aamir, Adverse Events Of Blood Transfusion And Blood Safety In Clinical Practice, Indo American Journal Of Pharmaceutical Sciences 5(8) (2018) 8254-8259.
P. Ripa, R. Ornello, D. Degan, C. Tiseo, J. Stewart, F. Pistoia, A. Carolei, S. Sacco, Migraine in menopausal women: a systematic review, International journal of women's health 7 (2015) 773.
M. Bousser, Migraine, female hormones, and stroke, Cephalalgia 19(2) (1999) 75-79.
M. Zehravi, M. Maqbool, I. Ara, Teenage menstrual dysfunction: an overview, International Journal of Adolescent Medicine and Health (2022).
M. Zehravi, M. Maqbool, I. Ara, An Update on Pain Control in Conservative Dentistry and Endodontics: A Review, The Indian Journal of Nutrition and Dietetics (2022) 114-125.
M. Maqbool, U. Ikram, A. Anwar, Adverse Drug Reaction Monitoring And Occurrence In Drugs Used In Pulmonary Disorders, Indo American Journal Of Pharmaceutical Sciences 5(8) (2018) 8060-8065.
I. Ara, M.A. Kalam, M. Maqbool, M. Zehravi, Phytochemical Standardization and Anti-Anxiety (Izterab-e-Nafsani) study of Aftimoon Hindi (Cuscuta reflexa Roxb.) on An Animal Model, CELLMED 11(3) (2021) 14.1-14.9.
R.A. Nicholson, D.C. Buse, F. Andrasik, R.B. Lipton, Nonpharmacologic treatments for migraine and tension-type headache: how to choose and when to use, Current treatment options in neurology 13(1) (2011) 28-40.
V.T. Martin, S. Wernke, K. Mandell, N. Ramadan, L. Kao, J. Bean, J. Liu, W. Zoma, R. Rebar, Defining the relationship between ovarian hormones and migraine headache, Headache: The Journal of Head and Face Pain 45(9) (2005) 1190-1201.
M. Maqbool, M. Zehravi, R. Maqbool, I. Ara, Study of adverse drug reactions in pulmonary medicine department of a Tertiary care hospital, Srinagar, Jammu & Kashmir, India, CELLMED 11(2) (2021) 8.1-8.5.
M.A. Dar, M. Maqbool, I. Gani, I. Ara, Menstruation hygiene and related issues in adolescent girls: A brief commentary, International Journal of Current Research in Physiology and Pharmacology (2023) 1-5.
M. Zehravi, M. Maqbool, I. Ara, An Overview about Safety Surveillance of Adverse Drug Reactions and Pharmacovigilance in India, The Indian Journal of Nutrition and Dietetics (2021) 408-418.
A.H. Calhoun, Menstrual migraine: update on pathophysiology and approach to therapy and management, Current treatment options in neurology 14(1) (2012) 1-14.
H. Yuan, N.M. Spare, S.D. Silberstein, Targeting CGRP for the prevention of migraine and cluster headache: a narrative review, Headache: The Journal of Head and Face Pain 59 (2019) 20-32.
A. Labastida-Ramírez, E. Rubio-Beltrán, C.M. Villalón, A. MaassenVanDenBrink, Gender aspects of CGRP in migraine, Cephalalgia 39(3) (2019) 435-444.
E. Dzoljic, S. Sipetic, H. Vlajinac, J. Marinkovic, B. Brzakovic, M. Pokrajac, V. Kostic, Prevalence of menstrually related migraine and nonmigraine primary headache in female students of Belgrade University, Headache: The Journal of Head and Face Pain 42(3) (2002) 185-193.
R. Parashar, P. Bhalla, N.K. Rai, A. Pakhare, R. Babbar, Migraine: is it related to hormonal disturbances or stress?, International journal of women's health 6 (2014) 921.
E.A. MacGregor, Oestrogen and attacks of migraine with and without aura, The Lancet Neurology 3(6) (2004) 354-361.
N.J. Colson, R.A. Lea, S. Quinlan, J. MacMillan, L.R. Griffiths, Investigation of hormone receptor genes in migraine, Neurogenetics 6(1) (2005) 17-23.
I. Ara, M. Maqbool, I. Gani, Specificity and Personalized medicine: a novel approach to Cancer management, International Journal of Current Research in Physiology and Pharmacology (2022) 11-20.
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