Main Article Content

Sandeep kumar Sharma
Niranjan singh
K V Thimmaraju
Mona Tilak


Introduction - Epilepsy is one of the most common disorders of the brain1. One of every ten people will have at least one epileptic seizure during a normal lifespan, and a third of these will develop epilepsy. In children the most common forms of convulsion are febrile seizures. Water electrolyte imbalance occurs during acute febrile illness and hypocalcaemia is one of them. Hypocalcaemia is also present in cases of seizures. To find out significance of calcium levels in cases of seizures this study was conducted.Aims and objectives – To assess the level of ionized calcium in cases of febrile seizure.Methods-This Case – Control study was conducted on fifty cases of febrile seizures and fifty age, weight matched controls  at Department of Biochemistry, Varun Arjun Medical College, Shahjahanpur,U.P., India.Results-Mean ionized calcium level was 4.62±0.26mg/dl and 4.88±0.27 mg/dl in study and control groups respectively and this difference was found statistically highly significant (p<0.001).Conclusion-The findings suggest that a considerable percentage of children having febrile seizures suffer from calcium deficiency.

Article Details

How to Cite
Sharma, S., singh, N., Thimmaraju, K., & Tilak, M. (2018). ASSESSMENT OF IONIZED CALCIUM STATUS IN FEBRILE SEIZURES. International Journal of Clinical and Biomedical Research, 4(3), 35-37.
Original Research Articles


1.World Health Organization. Atlas: Epilepsy Care in the World. Geneva: World Health Organization; 2005:91.

2.Johnston MV. Seizure in childhood: febrile seizure. 17th ed. In: Nelson‘s text book of pediatrics, Behrman RE, Kliegman RM, Jenson HB, eds. Pennsylvania: Saunders; 2004. pp. 1994-5.

3.Fallah R, Golestan M. Role of laboratory diagnostic tests in first febrile seizure. J Pediatr Neurol. 2008; 6(2): 129- 132.

4.Miri-Aliabad G, Khajeh A, Fayyazi A and Safdari L. Clinical, epidemiological and laboratory characteristics of the patients with febrile convulsion. J ComprPediatr. 2013; 4(3): 134-7.

5.Graves RC, Oehler K, Tingle LE. Febrile seizures: Risks evaluation and prognosis. Am Fam Physician. 2012; 85(2): 149-53.

6.Kafadar İ, Akıncı AB, Pekün F and Adal E. The role of serum zinc level in febrile convulsion etiology. J Pediatr Inf. 2012; 6: 90-93.

7.Salehiomran MR, Mahzari M. Zinc status in febrile seizure: A case-control study. Iran J Child Neurol. 2013; 7(4): 20-23.

8.Miri-Aliabad G, Khajeh A, Arefi M. Iron status and iron deficiency anemia in patients with febrile seizure. Zahedan J Res Med Sci. 2013; 15(9): 14-17.

9.Mahyar A, Ayazi P, Fallahi M and Javadi A. Risk factors of the first febrile seizures in Iranian children. Int J Pediatr. 2010; 2010: 1-3.

10.Vestergaard M, Hviid A, Madsen KM, et al. MMR vaccination and febrile seizures: Evaluation of susceptible subgroups and long-term prognosis. JAMA. 2004; 292(3): 351-357.

11.Burhanoğlu M, Tütüncüoğlu S, Coker C, et al. Hypozincaemia in febrile convulsion. Eur J Pediatr. 1996; 155(6): 498-501.

12.Malhotra Y, Campbell D. Pediatric hypocalcemia, 2014. Available at: Presentation/DDx/Workup/Treatment/Me dication. Accessed july 2017.

13. Akbayram S, Cemek M, Buyukben A, Aymelek F, Karaman S et al. Major and minor bio-element status in children with febrile seizure. Bratisl Lek Listy 2012; 113(7):421-3.