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Introduction: This study was undertaken primarily to compare the efficacy and safety of topical Lignocaine aerosol 15%, Lignocaine 2% with or without Adrenaline (1:80000) used in Temporary Anchorage Devices (TAD) placement in Orthodontic Treatment. Method: The study population included all patients of both gender and aged above 12 years, who were scheduled for placement of Temporary Anchorage Devices (TAD) in orthodontic treatment, and willing to participate in the study were included in the study. Depending on the local anaesthetic used, the patients were divided into Group 1 (Topical Lignocaine Aerosol 15% USP + Lignocaine 2% with Adrenaline), Group 2 (Lignocaine 2%) and Group 3 (Lignocaine 2% with Adrenaline). All the groups were assessed for immediate adverse drug reactions. The severity of adverse effects was graded by using Modified Treatment Tolerability Evaluation Score (MTTES) for the signs and symptoms Results: There was no statistically significant difference between age and gender of the three treatment groups. MTTES score was lowest in Group 2 followed by Group 3. It was significantly higher in Group 1. Conclusion: Group 1 (topical and infiltration lignocaine) and 3 combinations showed higher MTTES score for the adverse effect profile, whereas Group 2 appeared safer in terms of both the variables. Thus, use of topical and infiltration lignocaine raises concerns regarding safety of this combination.
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