ALTERATION IN SERUM ZINC AND COPPER CONCENTRATIONS AND EFFECT OF ORAL THERAPEUTIC SUPPLEMENTATION OF ZINC ON TRANSFUSION DEPENDANT BETA THALASSEMIA MAJOR PATIENTS

Main Article Content

Ghone Rahul A
Ghodake S S
Bhagart Sonali S
Karnik A C

Abstract

Zinc is one of the essential micronutrients in human and act as a cofactor for more than 300 enzymes and plays an essential role in human growth and development. It has been observed that there was low serum zinc and elevated  copper level in β-thalassemia major compared with normal. Zinc deficiency is considered one of the main factors contributing to growth, cardiovascular diseases, and puberty disorders in β-thalassemic patients. Aim: The goal of the study was to scrutinize the impact of serum zinc and copper concentration in patients with beta-thalassemia major and also to observe the effect of zinc supplementation on transfusion dependent beta-thalassemia patients for six months. Method: 52 beta-thalassemia major patients were studied before and after supplementation of zinc for six months, and status was compared with 52 age and sex-matched healthy normal.  Serum zinc and copper concentration were measured by atomic absorption spectrophotometry (AAS) method. Result: There was a significant depleted activity of  serum zinc level (p<0.001), and the copper level was increased significantly (p<0.001) in patients when compared with normal. After six months of supplementation of zinc, there was a significantly enhanced zinc concentration (p<0.001),and copper was marginally increased (p>0.05) when compared with normal and baselines. Conclusion: Beta Thalassemia  major children are on numerous blood transfusions all the way through their life. Due  to this  thalassemic children are at risk of secondary iron burden. This further leads to the  enhanced  oxidative stress. One of the way to may overcome this situation to supply regular zinc supplementation along with treatment, which may be helpful to manage the situation.


 

Article Details

How to Cite
A, G., S, G., S, B., & C, K. (2020). ALTERATION IN SERUM ZINC AND COPPER CONCENTRATIONS AND EFFECT OF ORAL THERAPEUTIC SUPPLEMENTATION OF ZINC ON TRANSFUSION DEPENDANT BETA THALASSEMIA MAJOR PATIENTS. International Journal of Clinical and Biomedical Research, 6(2), 10-12. https://doi.org/10.31878/ijcbr.2020.62.03

References

Asmaa Nafady, Sanaa Shaker Ali, Hosney Mohammed, Ahmed EI Masry, Khaled Abdel Baseer et al. Oxidative stress in pediatric patients with β- thalassemia major. Egyptian Journal of Haematology 2017; 42 (3): 123-7
Mahmood Asif, Zahid Mansoor, UzmaS haheen, Amama Kawal. Effect of multiple blood transfusions on hormonal profile in thalassemia children. Rawal Medical Journal 2014;39(3): 265-9
Hasan F AL-Azzawie, Noor A Salman. Association of vitamin profile with oxidant/ Antioxidant status in Iraqi β- thalassemic major children. J. Pharmacology and Clinical Research 2017;4(4): 1-5
Mamta Choudhary, Raj Kumar Vyas, Anil Lahoti. Correlation of oxidative stress with serum antioxidant enzymes level in thalassemia in a tertiary level hospital of western Rajasthan. International Journal of Biotechnology and Biochemistry, 2017;13(2):155-65
Livrea MA, Tesoriere L, Pintaudi AM et. al. Oxidative stress and Antioxidant status in beta thalassemia major: Iron overload and depletion of lipid soluble antioxidants. Blood 1996; 88(9):3608-14
Widad NM, Al-Naama L, Meaad. Trace element in patients with beta thalassemia major. Haem.2003;6(3):376-83
Das N, Chowdhury TD, Chattopadhyay A, Datta. Attenuation of oxidation stress- induced changes in thalassemic erythrocytes by Vitamin E. Pol J Pharmocol. 2004;56: 85-96
Ambekar SS, Phadke MA, Balpande DN, Mokashi GD, Khedkar VA, et al. The prevalence and Heterogeneity of Beta Thalassemia Mutation in The Western Maharashtra Population: A hospital-based study. IJHG 2001;1(3):219-23
Shazia Q,Mohammad ZH,Taibur Rahman, Hossain Uddin Shekhar. Correlation of Oxidative Stress with Serum Trace Element Levels and Antioxidant Enzyme Status in Beta Thalassemia Major Patients: A Review of the Literature. Hindawi Publishing Corporation Anemia. 2012;1:1-7
Hidhab Jawad Muhssen, Qasim M. Hashim Al Moussawi, Ashwaq Ali Hussein, Ali Hadi Mahdi. Assessment of Serum Zinc Level in Children with Thalassemia Major Receiving Oral Chelation and Their Sibling in AL-Najaf City. Int Journal of Science and Research 2016;7(1):746-51
Attakorn Palasuwan, Methee Sriprapun, Winai Dahlan, Rataya Luechapudiporn et al. Antioxidant protection in hemoglobin E trait subjects after vitamin E supplementation. Southeast Asian J Trop Med Public Health 2008;39(1):82-9
Jilani T, Iqbal M. Does vitamin E have a role in the treatment and prevention of anemia?. Pakistan J. of Pharmaceutical Sci. 2011;24(2): 237-42
Varley H. Atomic Absorption Spectroscopy. In: Practical clinical biochemistry. Heineman professional publishing1998; 6thEd:p 167-74
Sonali S Bhagat, Purnima Dey Sarkar, Adinath N Suryakar, Ghone RA et al.Special Effects of Oral Therapeutic Supplementation of Antioxidants on Attenuation of Iron Overload in Homozygous Beta Thalassemia. International Journal of Health Sciences & Research, 2012;37(2):36-8
Elijah KG, Sushrita Neogi, AshutoshLal, Annie Higa. nutritional deficiencies are common in patients with transfusion dependant thalassemia and associated with iron overload. J of Food and Nutrition research 2018; 6(10):674-81
Mohammadreza Rashidi, Maryam A, Maryam R, Seyed RA. Effects of vitamin E and zinc supplementation on antioxidants in beta thalassemia major patients. Iran J Pediatr 2011;21(1):8-14
Abolfazl M, Parviz A, Ali- Asghar P. Zinc and copper status in children with beta – thalassemia major. Iran J Pediatr 2010;20(3):297-302
Ghone RA, Kumbar KM, Suryakar AN, Katkam RV, Joshi NG. Oxidative stress and disturbance in antioxidant balance in beta thalassemia major. Indian Journal of Clinical Biochemistry 2008;23(4):337-40.
Foroogh SH, Maryam A, Seyed MH. Serum and urine level of zinc in patients with minor beta thalassemia in Ali-asghar Hospital during the years 2005-2006. Iranian J of Pathology 2007;2(2):54
Anuja Adarsh, Asha Khubchandani, Disha Gajjar. Alteration in trace elements in thalassemia major patients after chelation therapy. Int J Med SciEduc 2019; 6(1):63-5