EFFECT OF 5 WEEKS RADIATION THERAPY ON PULMONARY FUNCTIONS IN BREAST CANCER PATIENTS: A PILOT STUDY
Radiation therapy on pulmonary function in breast cancer
DOI:
https://doi.org/10.31878/ijcbr.2020.64.04Keywords:
Breast Cancer,Radiation Therapy,Pulmonary Function TestAbstract
ABSTRACT:
BACKGROUND: The lung has a very little regenerative capacity; it cannot tolerate long doses of radiation. The critical injuries that eventually lead to impaired ventilation and diffusion capacity are related to total dose, its fractionation, and volume of lung irradiated. The absorption of ionizing radiation causes immediate subcellular and cellular damage while its gross morphological expression in terms of tissue injury.
Aim of study: To observe the effect of 5 weeks of Radiation Therapy on Pulmonary Functions in breast cancer patients Methodology: The study was carried out on ten subjects ranging in the age group of 35-65 years where PFT parameters were recorded initially and at the end of every week for five weeks. Then parameters were compared pre radiation and every week after the radiation therapy for five weeks.
RESULT: Data was analyzed in terms of the mean difference. Statistically, there were no significant changes seen in the PFT parameter values that are pre- radiation and post-radiation every week for five weeks and the p values obtained were for following parameters 1) FVC – 0.487 2) FEV1 – 0.863 3) FEV1/FVC – 0.487 4) FEF25-75% - 5) PEFR- .
CONCLUSION: There were no significant changes that were found in the parameters of the pulmonary function test. Changes in lung volume and capacities are expected after Radiation therapy that is risk of damaging pulmonary parenchyma and losing type 2 pneumocytes but patient never present changes due to compensation in relation to healthy changes which did not receive radiation.
KEY WORDS: Breast Cancer,Radiation Therapy,Pulmonary Function Test
Downloads
Downloads
Published
Issue
Section
License
The journal allows the author(s) to hold the copyright without restrictions and will retain publishing rights without restrictions.
The submitted papers are assumed to contain no proprietary material unprotected by patent or patent application; responsibility for technical content and for protection of proprietary material rests solely with the author(s) and their organizations and is not the responsibility of the journal. The main (first/corresponding) author is responsible for ensuring that the article has been seen and approved by all the other authors. It is the responsibility of the author to obtain all necessary copyright release permissions for the use of any copyrighted materials in the manuscript prior to the submission.
What are my rights as an author?
It is important to check the policy for the journal to which you are submitting or publishing to establish your rights as
Author. Journal's standard policies allow the following re-use rights:
- The journal allows the author(s) to hold the copyright without restrictions.
- The journal allows the author(s) to obtain publishing rights without restrictions.
- You may do whatever you wish with the version of the article you submitted to the journal.
- Once the article has been accepted for publication, you may post the accepted version of the article on your own personal website, your department's website or the repository of your institution without any restrictions.
- You may not post the accepted version of the article in any repository other than those listed above (i.e. you may not deposit in the repository of another institution or a subject-matter repository) until 12 months after publication of the article in the journal.
- You may use the published article for your own teaching needs or to supply on an individual basis to research colleagues, provided that such supply is not for commercial purposes.