Original Research Articles
NON-HODGKIN LYMPHOMA IN THE CONTEXT OF HEPATITIS B AND HIV CO-INFECTION: A RETROSPECTIVE OBSERVATIONAL STUDY OF 410 CASES
Doddappa Mallappa Bannigida
Assistant Professor, Department of Biochemistry, S R Patil Medical College, Hospital and Research Center, Badagandi, India
Shashikala Hanumantappa Madivalar
Assistant Professor, Department of Pathology, Koppal Institute of Medical Science, Koppal, India.
Vijayashree Shivappa Neeravari
Associate Professor, Department of Pathology, Koppal Institute of Medical Science, Koppal, India.
Lakshmi Rao
Professor and senior consultant, Department of Pathology, Armed forces Hospital, Muscat, Oman.
Published: 2026-07-26
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Abstract
Background: Non-Hodgkin lymphomas (NHL) represent a group of lymphoproliferative disorders, with a limited understanding of their clinical spectrum, primary extra nodal variety, particularly in developing countries. The objective of the study was to evaluate the Association of Hepatitis B and HIV infection in patients diagnosed with non-Hodgkin lymphoma.
Method: In this Observational Retrospective study of diagnosed cases of NHL was conducted on 410 cases and we extracted information from electronic medical records. Tumors were reclassified according to the WHO.
Results: In the present study 5.6% of NHL cases were associated with HIV positive status and 1.7% of NHL cases were associated with HBsAg positive status. Extra nodal lymphomas were more common in HIV+ve patients with 67.8% (38/56) and DLBCL-ABC being the commonest subtype. In HBsAG+ve patients only nodal lymphomas were seen with Follicular lymphoma being the commonest subtype.
Conclusion: The study highlights the HBsAg +ve patients are associated with nodal and low-grade NHL, with Follicular lymphoma being the commonest subset. Whereas extra nodal and high-grade NHL are common among the retro positive cases with DLBCL-ABC being the commonest subset. In addition, it shows the higher risk for NHL represents for improving, prevention, diagnosis and management of HIV and HbsAg patients.
Keywords
Hepatitis B virus,HbsAg, HIV, non-Hodgkin lymphoma.
How to Cite
Doddappa Mallappa Bannigida, Shashikala Hanumantappa Madivalar, Vijayashree Shivappa Neeravari, & Lakshmi Rao. (2026). NON-HODGKIN LYMPHOMA IN THE CONTEXT OF HEPATITIS B AND HIV CO-INFECTION: A RETROSPECTIVE OBSERVATIONAL STUDY OF 410 CASES. International Journal of Clinical and Biomedical Research, 11(3), 164–169. Retrieved from https://sumathipublications.com/index.php/ijcbr/article/view/607
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