PREVENTIVE EFFECTS OF THE AQUEOUS EXTRACT OF CINNAMOMUM ZEYLANICUM BARK ON DEXAMETHASONE INDUCED INSULIN RESISTANCE IN WISTAR ALBINO RATS

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Rajasekhar CH
Nagendranayak IM
Rajesh B
Kokila B Nagraju
Guruprasad N Banavasi
Hemanth Kumar V

Abstract

Objectives: To evaluate the preventive effects of aqueous extract of Cinnamomum zeylanicum bark on dexamethasone induced insulin resistance and to compare it with rosiglitazone. Methods: The animals were categorized into two series of dexamethasone (dexamethasone 4mg/kg, dexamethasone 8mg/kg series) with 5 groups in each [plain control, dexamethasone 4/8mg/kg as per series, rosiglitazone 8mg/kg and 16mg/kg, cinnamon bark extract (CZE) 250mg/kg BW]. Six animals were studied in each group. In a12 day study period, rosiglitazone and CZE groups received respective drug treatments and dexamethasone dosing (4mg/kg or 8mg/kg) was started from day 7onwards. On day 12, fasting blood, urine and post IPGTT blood samples were collected and processed for glucose, insulin and ketone estimations. Results: In both series, CZE 250mg/kg treatment showed significant reduction in mean fasting glucose and insulin compared to rosiglitazone 8mg/kg and 16mg/kg groups and dexamethasone controls (4mg/kg, 8mg/kg groups) (P<0.05). The fall in glucose and insulin levels observed with CZE treatment at 30, 60 min post IPGTT in both series were significant compared to rosiglitazone and dexamethasone treatment groups (P<0.05). Glycosuria and ketonuria were absent in CZE groups, whereas these were reduced significantly in rosiglitazone groups compared to dexamethasone groups (P<0.05). Conclusion: The aqueous extract of C. zeylanicum bark prevented the insulin resistance as evidenced by reduced fasting and post IPGTT glucose and insulin levels in steroid induced insulin resistance model.


KEYWORDS: Glucose uptake; Cinnamon bark; Rosiglitazone; Hyperinsulinemia; Hyperglycemia.

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How to Cite
CH, R., IM, N., B, R., B Nagraju, K., N Banavasi, G., & Kumar V, H. (2015). PREVENTIVE EFFECTS OF THE AQUEOUS EXTRACT OF CINNAMOMUM ZEYLANICUM BARK ON DEXAMETHASONE INDUCED INSULIN RESISTANCE IN WISTAR ALBINO RATS. International Journal of Clinical and Biomedical Research, 1(4), 14-20. Retrieved from https://sumathipublications.com/index.php/ijcbr/article/view/87