Adverse Reactions Caused by Antiepileptic Medications in Real-World Medical Settings
Keywords:
adverse reactions, anti-epileptic drugs, carbamazepine, phenytoinAbstract
Epilepsy is a relatively common condition characterized by a tendency for recurrent seizures, which is due to the disturbance of spread of electrical discharge of the cortical neurons. Up to 80% of people with epilepsy are able to control their condition with anti epileptic drugs (AEDs). The growing number of newly approved drugs for various illnesses coupled with the complex treatment options have contributed to the increased risk of adverse drug reactions (ADRs). AEDs have a narrow therapeutic index with wide spectrum of ADRs. 10-30% of epileptic patients discontinue their initially prescribed AEDs due to ADRs. These ADRs can be the cause of non-adherence and subjective distress. The newer generation AEDs have reduced adverse events, fewer drug interactions if any and thus improved safety. Comparison of adverse effects in patients taking AEDs with adverse events in control groups is helpful; however, data from controlled studies are often lacking for most AEDs. Because of these limitations, the clinician must adopt a preventative and early detection approach based on some general principles. This review outlines various adverse reactions related to the use of Anti-epileptic drugs.
Keywords: adverse reactions, antiepileptic drugs, carbamazepine, phenytoin
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Copyright (c) 2023 Mashooq Ahmad Mir, Abrar Bashir Malik, Zulfkar Qadrie, Mohd Altaf Dar
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